Results 51 to 60 of about 4,732,906 (245)
On behaviour of the maximal term of Dirichlet series derivative
Matematychni Studii, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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Stability degree of maximal term of Dirichlet series
Ufa Mathematical JournalWe study the stability of a maximal term of a Dirichlet series with positive exponents, the sum of which is an entire function. For a class of entire Dirichlet series defined by a certain convex growth majorant, we prove a theorem on the quantitative estimate of the equivalence degree (outside of some exceptional $c_{q}$-set) of the logarithms of ...
Narkes Nurmukhametovna Aitkuzhina +1 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the maximal term of series in systems of functions in a disk
Carpathian Mathematical PublicationsFor an entire transcendental function $f$ and for a sequence $(\lambda_n)$ of positive numbers increasing to $+\infty$, a series $A(z)=\sum\limits_{n=1}^{\infty}a_nf(\lambda_n z)$ is said to be regularly convergent in $\{z: |z|<R[A]<+\infty\}$, if $\mathfrak{M}(r,A)=\sum\limits_{n=1}^{\infty} |a_n|M_f(r\lambda_n)<+\infty$ for all $r\in [0, R[A]
M.M. Sheremeta, M.S. Dobushovskyy
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Achieving Long-Term Fairness in Submodular Maximization Through Randomization
Submodular function optimization has numerous applications in machine learning and data analysis, including data summarization which aims to identify a concise and diverse set of data points from a large dataset. It is important to implement fairness-aware algorithms when dealing with data items that may contain sensitive attributes like race or gender,
Shaojie Tang 0001 +2 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
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