Results 111 to 120 of about 5,399,796 (309)

Optimal Consensus Set for Annulus Fitting

open access: yes, 2011
International audienceAn annulus is defined as a set of points contained between two circles. This paper presents a method for fitting an annulus to a given set of points in a 2D images in the presence of noise by maximizing the number of inliers, namely
Andres, Eric   +5 more
core   +1 more source

Maximizing without Borders: Evidence that Maximizing Transcends Decision Domains [PDF]

open access: yes, 2018
Do maximizers maximize across decision domains? An assumption underlying the literature on maximizing is that the tendency to strive to make the best choice spans domains. The current research provides a direct test of this assumption by examining the
Kokkoris, Michail
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Competitive Prices as Profit-Maximizing Cartel Prices [PDF]

open access: yes, 2010
Even under antitrust enforcement, firms may still form a cartel in an infinitely-repeated oligopoly model when the discount factor is sufficiently close to one. We present a linear oligopoly model where the profit-maximizing cartel price converges to the
Wen, Quan   +5 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Germination and Seedling Characters of Different Wheat Cultivars under Salinity Stress [PDF]

open access: yes, 2012
The impact of salt stress under different salinity level (2, 4, 6, 8, 10, 12 and 14 dS/m-1 NaCl) on eleven varieties of bread wheat (Triticum aestivum L.) viz., Sakha 93, Gemmeza 7, Egaseed 7, Sakha 94, Gemmeza 10, Egaseed 3, Masr 2, Masr 1, Gemmeza 9 ...
A.A. Kandil, A.E. Sharief, M.A. Elokda
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Constrained Multiobjective Biogeography Optimization Algorithm

open access: yesThe Scientific World Journal, 2014
Multiobjective optimization involves minimizing or maximizing multiple objective functions subject to a set of constraints. In this study, a novel constrained multiobjective biogeography optimization algorithm (CMBOA) is proposed.
Hongwei Mo   +4 more
doaj   +1 more source

Maximizing vector distances for purpose of searching - A study of differential evolution suitability

open access: yes, 2014
This paper explores suitability of using of differential evolution for maximizing of weighted distances of vectors in a set of vectors. Increase in vector distances simplifies searching for the best matching vector what is a common task in many areas ...
Jašek, Roman   +5 more
core   +1 more source

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