Results 81 to 90 of about 4,739,268 (353)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Rapid Algorithm for Generating Entry Landing Footprints Satisfying the No-Fly Zone Constraint
International Journal of Aerospace Engineering, 2021 An online estimation algorithm of landing footprints based on the drag acceleration-energy profile is proposed for an entry hypersonic vehicle. Firstly, based on the Evolved Acceleration Guidance Logic for Entry (EAGLE), drag acceleration-energy profiles
Shengnan Fu +3 more
doaj +1 more source
Particle Acceleration in Gamma-Ray Burst Jets
, 2005 Gradual shear acceleration of energetic particles in gamma-ray burst (GRB) jets is considered. Special emphasis is given to the analysis of universal structured jets, and characteristic acceleration timescales are determined for a power-law and a ...
Duffy, Peter, Rieger, Frank M.
core +1 more source
Evidence for anisotropy of cosmic acceleration [PDF]
Astronomy & Astrophysics, 2018 Observations reveal a “bulk flow” in the local Universe which is faster and extends to much larger scales than are expected around a typical observer in the standard ΛCDM cosmology.
J. Colin +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Applied SciencesThe mold clamping mechanism is crucial in injection molding machines and significantly influences molding. This research optimizes the Stephenson-chain mechanism with double-toggle effects, particularly focusing on acceleration and driving force.
Tzu-Hsia Chen, Po-Cheng Lai
doaj +1 more source
Enhancement of maximum attainable ion energy in the radiation pressure acceleration regime using a guiding structure. [PDF]
Physical Review Letters, 2013 Radiation pressure acceleration is a highly efficient mechanism of laser-driven ion acceleration, with the laser energy almost totally transferrable to the ions in the relativistic regime. There is a fundamental limit on the maximum attainable ion energy,
S. Bulanov +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Influence of Different Driving Parameters on Traffic with a Cellular Automata Model
Applied SciencesReliable traffic simulations with high-quality results contribute to the understanding of the traffic system and effective planning. In this article, firstly, an existing cellular automata (CA) model is modified to perform a comprehensive analysis of the
Andrej Rigler, Goran Turk
doaj +1 more source