Results 81 to 90 of about 1,156,434 (264)

Note on the product of the largest and the smallest eigenvalue of a graph

open access: yesSpecial Matrices
In this note, we use eigenvalue interlacing to derive an inequality between a graph’s maximum degree and its maximum and minimum adjacency eigenvalues. The equality case is fully characterized.
Abiad Aida   +2 more
doaj   +1 more source

The Smallest Harmonic Index of Trees with Given Maximum Degree

open access: yesDiscussiones Mathematicae Graph Theory, 2018
The harmonic index of a graph G, denoted by H(G), is defined as the sum of weights 2/[d(u) + d(v)] over all edges uv of G, where d(u) denotes the degree of a vertex u. In this paper we establish a lower bound on the harmonic index of a tree T.
Rasi Reza, Sheikholeslami Seyed Mahmoud
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Lawrence lifts, matroids, and maximum likelihood degrees

open access: yesAlgebraic Statistics
23 pages, 5 figures. Comments welcome!
Brysiewicz, Taylor, Maraj, Aida
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Sparse Vertex Cutsets and the Maximum Degree

open access: yesThe Electronic Journal of Combinatorics
We show that every graph $G$ of maximum degree $\Delta$ and sufficiently large order has a vertex cutset $S$ of order at most $\Delta$ that induces a subgraph $G[S]$ of maximum degree at most $\Delta-3$. For $\Delta\in \{ 4,5\}$, we refine this result by considering also the average degree of $G[S]$.
Bessy, Stéphane   +3 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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