Results 51 to 60 of about 3,290,751 (273)

Entropy-Based Temporal Downscaling of Precipitation as Tool for Sediment Delivery Ratio Assessment

open access: yesEntropy, 2021
Many regions around the globe are subjected to precipitation-data scarcity that often hinders the capacity of hydrological modeling. The entropy theory and the principle of maximum entropy can help hydrologists to extract useful information from the ...
Pedro Henrique Lima Alencar   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Some Notes on Maximum Entropy Utility

open access: yesEntropy, 2019
The maximum entropy principle is effective in solving decision problems, especially when it is not possible to obtain sufficient information to induce a decision.
Eun Young Kim, Byeong Seok Ahn
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Maximum Entropy Theory of Ecology: A Reply to Harte

open access: yesEntropy, 2018
In a paper published in this journal, I addressed the following problem: under which conditions will two scientists, observing the same system and sharing the same initial information, reach the same probabilistic description upon the application of the ...
Marco Favretti
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Atomic Structure Modeling of Multi-Principal-Element Alloys by the Principle of Maximum Entropy

open access: yesEntropy, 2013
Atomic structure models of multi-principal-element alloys (or high-entropy alloys) composed of four to eight componential elements in both BCC and FCC lattice structures are built according to the principle of maximum entropy.
Shaoqing Wang
doaj   +1 more source

(Generalized) Maximum Cumulative Direct, Residual, and Paired Φ Entropy Approach

open access: yesEntropy, 2020
A distribution that maximizes an entropy can be found by applying two different principles. On the one hand, Jaynes (1957a,b) formulated the maximum entropy principle (MaxEnt) as the search for a distribution maximizing a given entropy under some given ...
Ingo Klein, Monika Doll
doaj   +1 more source

How biased are maximum entropy models? [PDF]

open access: yes, 2011
Maximum entropy models have become popular statistical models in neuroscience and other areas in biology, and can be useful tools for obtaining estimates of mutual information in biological systems.
Peter E. Latham   +8 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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