Results 101 to 110 of about 1,223,755 (370)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Targeted maximum likelihood based estimation for longitudinal mediation analysis

Journal of Causal Inference
Causal mediation analysis with random interventions has become an area of significant interest for understanding time-varying effects with longitudinal and survival outcomes.
Wang Zeyi, Laan Lars van der, Petersen Maya, Gerds Thomas, Kvist Kajsa, Laan Mark van der   +5 more
doaj   +1 more source

Maximum likelihood approach to DoA estimation using lens antenna array

EURASIP Journal on Wireless Communications and Networking, 2019
Massive antenna array has been proposed to improve the spectral efficiency and link reliability in wireless communication systems. However, using large antenna arrays incurs additional cost in terms of signal processing and hardware complexity.
Zheng-Ming Jiang, Peichang Zhang, Mohamed Rihan, Lei Huang, Jihong Zhang   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Exploration Through Reward Biasing: Reward-Biased Maximum Likelihood Estimation for Stochastic Multi-Armed Bandits [PDF]

, 2019
Xi Liu, Ping-Chun Hsieh, Anirban Bhattacharya, P. R. Kumar   +3 more
openalex   +1 more source

Maximum Likelihood Estimation of Latent Affine Processes [PDF]

This article develops a direct filtration-based maximum likelihood methodology for estimating the parameters and realizations of latent affine processes.
David S. Bates
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Tractable Maximum Likelihood Estimation for Latent Structure Influence Models with Applications to EEG & ECoG processing [PDF]

, 2022
Sajjad Karimi, Mohammad Bagher Shamsollahi   +1 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

tmle : An R Package for Targeted Maximum Likelihood Estimation

Journal of Statistical Software, 2012
Targeted maximum likelihood estimation (TMLE) is a general approach for constructing an efficient double-robust semi-parametric substitution estimator of a causal effect parameter or statistical association measure. tmle is a recently developed R package
Susan Gruber, Mark J. van der Laan
doaj