Results 101 to 110 of about 54,912 (316)

Efficiency evaluation of the unconditional maximum likelihood estimator for near-field source DOA estimation [PDF]

open access: yes, 2006
"In this paper, we address the problem of closely spaced source localization using sensor array processing. In particular, the performance efficiency (measured in terms of the root mean square error) of the unconditional maximum likelihood (UML ...
JOSE GUADALUPE ARCEO OLAGUE
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Estimating the Parameters of Mixture Gamma Distributions Using Maximum Likelihood and Bayesian Method [PDF]

open access: yesالمجلة العراقية للعلوم الاحصائية
     This paper focuses on the mixture Gamma distribution and uses the maximum likelihood and Bayesian techniques to estimate its parameters.
Nagham Ibrahim Abdulla Najm   +1 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Likelihood decision functions [PDF]

open access: yes, 2012
In both classical and Bayesian approaches, statistical inference is unified and generalized by the corresponding decision theory. This is not the case for the likelihood approach to statistical inference, in spite of the manifest success of the ...
Cattaneo, Marco E. G. V.
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

A Pairwise Difference Estimator for Partially Linear Spatial Autoregressive Models [PDF]

open access: yes
Su and Jin (2010) develop for partially linear spatial autoregressive (PL-SAR) model a profile quasimaximum likelihood based estimation procedure. More recently, Su (2011) proposes for this model a semiparametric GMM estimator.
Zhengyu Zhang
core  

Optimal Shrinkage Estimations for the Parameters of Exponential Distribution Based on Record Values

open access: yesRevista Colombiana de Estadística
This paper studies shrinkage estimation after the preliminary test for the parameters of exponential distribution based on record values. The optimal value of shrinkage coefficients is also obtained based on the minimax regret criterion.
HOJATOLLAH ZAKERZADEH   +2 more
doaj  

Experiment-selector cross-validated targeted maximum likelihood estimator for hybrid RCT-external data studies

open access: yesJournal of Causal Inference
Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined with external data) with the optimal bias-variance tradeoff, we develop a ...
Dang Lauren Eyler   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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