Results 101 to 110 of about 2,646,945 (311)

Tropical Toric Maximum Likelihood Estimation

SIAM Journal on Applied Algebra and Geometry
We consider toric maximum likelihood estimation over the field of Puiseux series and study critical points of the likelihood function using tropical methods. This problem translates to finding the intersection points of a tropical affine space with a classical linear subspace.
Emma Boniface, Karel Devriendt, Serkan Hosten   +2 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Experiment-selector cross-validated targeted maximum likelihood estimator for hybrid RCT-external data studies

Journal of Causal Inference
Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined with external data) with the optimal bias-variance tradeoff, we develop a ...
Dang Lauren Eyler, Tarp Jens Magelund, Abrahamsen Trine Julie, Kvist Kajsa, Buse John B., Petersen Maya, van der Laan Mark   +6 more
doaj   +1 more source

Estimating the Parameters of Mixture Gamma Distributions Using Maximum Likelihood and Bayesian Method [PDF]

المجلة العراقية للعلوم الاحصائية
     This paper focuses on the mixture Gamma distribution and uses the maximum likelihood and Bayesian techniques to estimate its parameters.
Nagham Ibrahim Abdulla Najm, Raya Salim Al_Rassam   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

A Pairwise Difference Estimator for Partially Linear Spatial Autoregressive Models [PDF]

Su and Jin (2010) develop for partially linear spatial autoregressive (PL-SAR) model a profile quasimaximum likelihood based estimation procedure. More recently, Su (2011) proposes for this model a semiparametric GMM estimator.
Zhengyu Zhang
core  

Penalized Maximum Likelihood Estimator for Normal Mixtures

, 2003
International audienceThe estimation of the parameters of a mixture of Gaussian densities is considered, within the framework of maximum likelihood. Due to unboundedness of the likelihood function, the maximum likelihood estimator fails to exist.
Ridolfi, Andrea, Idier, Jérôme, Ciuperca, Gabriela   +2 more
core   +1 more source

Likelihood inference for small variance components

, 2000
In this paper, we develop likelihood-based methods for making inferences about the components of variance in a general normal mixed linear model. In particular, we use local asymptotic approximations to construct confidence intervals for the components ...
Stern, S.E., Welsh, A.H.
core   +1 more source

Optimal Shrinkage Estimations for the Parameters of Exponential Distribution Based on Record Values

Revista Colombiana de Estadística
This paper studies shrinkage estimation after the preliminary test for the parameters of exponential distribution based on record values. The optimal value of shrinkage coefficients is also obtained based on the minimax regret criterion.
HOJATOLLAH ZAKERZADEH, ALI AKBAR JAFARI, MAHDIEH KARIMI   +2 more
doaj