Results 91 to 100 of about 2,646,945 (311)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Maximum Likelihood Estimation of Latent Affine Processes [PDF]

This article develops a direct filtration-based maximum likelihood methodology for estimating the parameters and realizations of latent affine processes.
David S. Bates
core  

Modified maximum likelihood estimator under the Jones and Faddy's skew t-error distribution for censored regression model. [PDF]

J Appl Stat, 2021
Acitas S, Yenilmez I, Senoglu B, Kantar YM.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

"A New Light from Old Wisdoms : Alternative Estimation Methods of Simultaneous Equations with Possibly Many Instruments" [PDF]

We compare four dffierent estimation methods for a coefficient of a linear structural equation with instrumental variables. As the classical methods we consider the limited information maximum likelihood (LIML) estimator and the two-stage least squares ...
Naoto Kunitomo, T. W. Anderson, Yukitoshi Matsushita   +2 more
core  

Estimation of the Parameters of Burr Type III Distribution Based on Dual Generalized Order Statistics

The Scientific World Journal, 2014
The estimation of the parameters of Burr type III distribution based on dual generalized order statistics is considered by using the maximum likelihood (ML) approach as well as the Bayesian approach.
Chansoo Kim, Woosuk Kim
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

"On the Asymptotic Optimality of the LIML Estimator with Possibly Many Instruments" [PDF]

We consider the estimation of the coefficients of a linear structural equation in a simultaneous equation system when there are many instrumental variables.
Naoto Kunitomo, T. W. Anderson, Yukitoshi Matsushita   +2 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Asymptotic properties of maximum likelihood estimator for some discrete distributions generated by

Statistica, 2013
In large-scale biomolecular sysrems there are frequency distribuions with properties like Stable Laws. It is of interest to construct such frequency distributions. In the present article we consider Cauchy stable law. The large-sample distribution of the
Davood Farbod, Karen V. Gasparian
doaj   +1 more source