Results 71 to 80 of about 41,346 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Information Theory Estimators for the First-Order Spatial Autoregressive Model

Entropy, 2012
Information theoretic estimators for the first-order spatial autoregressive model are introduced, small sample properties are investigated, and the estimator is applied empirically. Monte Carlo experiments are used to compare finite sample performance of
Evgeniy V. Perevodchikov, Thomas L. Marsh, Ron C. Mittelhammer   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bayesian and Classical Estimation of Stress-Strength Reliability for Inverse Weibull Lifetime Models

Algorithms, 2017
In this paper, we consider the problem of estimating stress-strength reliability for inverse Weibull lifetime models having the same shape parameters but different scale parameters.
Qixuan Bi, Wenhao Gui
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Geodesic distances in the maximum likelihood estimator of intrinsic dimensionality

Nonlinear Analysis, 2011
While analyzing multidimensional data, we often have to reduce their dimensionality so that to preserve as much information on the analyzed data set as possible. To this end, it is reasonable to find out the intrinsic dimensionality of the data.
Rasa Karbauskaitė, Gintautas Dzemyda, Edmundas Mazėtis   +2 more
doaj  

Various methods of estimating constant-partially accelerated life tests of the Odd Kappa-Exponential distribution based on complete data

Results in Engineering
This study aims to address a central issue in continuous partially accelerated life testing for complete failure data by developing and comparing eight estimating methods for the two-parameter Odd Kappa-Exponential distribution, which features a flexible
Ali A. Al-Shomrani
doaj   +1 more source

Large Deviations and Berry–Esseen Inequalities for Estimators in Nonlinear Nonhomogeneous Diffusions

Revstat Statistical Journal, 2007
Bounds on the large deviations probability of the maximum likelihood estimator and regular Bayes estimators, and Berry–Esseen type bound for the suitably normalized maximum likelihood estimator of a parameter appearing nonlinearly in the nonhomogeneous ...
Jaya P.N. Bishwal
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source