Results 51 to 60 of about 39,628 (252)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Large Deviations and Berry–Esseen Inequalities for Estimators in Nonlinear Nonhomogeneous Diffusions
Revstat Statistical Journal, 2007 Bounds on the large deviations probability of the maximum likelihood estimator and regular Bayes estimators, and Berry–Esseen type bound for the suitably normalized maximum likelihood estimator of a parameter appearing nonlinearly in the nonhomogeneous ...
Jaya P.N. Bishwal
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Results in EngineeringThis study aims to address a central issue in continuous partially accelerated life testing for complete failure data by developing and comparing eight estimating methods for the two-parameter Odd Kappa-Exponential distribution, which features a flexible
Ali A. Al-Shomrani
doaj +1 more source
Bayesian and Classical Estimation of Stress-Strength Reliability for Inverse Weibull Lifetime Models
Algorithms, 2017 In this paper, we consider the problem of estimating stress-strength reliability for inverse Weibull lifetime models having the same shape parameters but different scale parameters.
Qixuan Bi, Wenhao Gui
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Geodesic distances in the maximum likelihood estimator of intrinsic dimensionality
Nonlinear Analysis, 2011 While analyzing multidimensional data, we often have to reduce their dimensionality so that to preserve as much information on the analyzed data set as possible. To this end, it is reasonable to find out the intrinsic dimensionality of the data.
Rasa Karbauskaitė +2 more
doaj
A Comparison Between Two Shape Parameters Estimators for (Burr-XII) Distribution
مجلة بغداد للعلوم, 2020 This paper deals with defining Burr-XII, and how to obtain its p.d.f., and CDF, since this distribution is one of failure distribution which is compound distribution from two failure models which are Gamma model and weibull model. Some equipment may have
Shurooq Ahmed Kareem
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source