Results 71 to 80 of about 1,626,050 (291)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Estimating the Parameters of Mixture Gamma Distributions Using Maximum Likelihood and Bayesian Method [PDF]
المجلة العراقية للعلوم الاحصائيةThis paper focuses on the mixture Gamma distribution and uses the maximum likelihood and Bayesian techniques to estimate its parameters.
Nagham Ibrahim Abdulla Najm +1 more
doaj +1 more source
Comparison of methods to extract an asymmetry parameter from data
, 2011 Several methods to extract an asymmetry parameter in an event distribution function are discussed and compared in terms of statistical precision and applicability.
Pretz, Jörg
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Estimating the Transitional Probabilities of the E.Coli Gene Chain by Maximum Likelihood Method and Bayes Method [PDF]
المجلة العراقية للعلوم الاحصائيةThe transition matrix estimators of the Markov chain are not accurate and the transition matrix is considered given. There are many methods that are used to estimate the transition probabilities matrix for different cases, the most famous of which is the
Alaa Farhan Ahmed, Muthanna Sulaiman
doaj +1 more source
EMPIRICAL LIKELIHOOD ESTIMATORS OF THE LINEAR SIMULTANEOUS EQUATIONS MODEL [PDF]
Information theoretic estimators are specified for a system of linear simultaneous equations, including maximum empirical likelihood, maximum empirical exponential likelihood, and maximum log Euclidean likelihood.
Judge, George G. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Exact maximum-likelihood method to detect patterns in real networks [PDF]
In order to detect patterns in real networks, randomized graph ensembles that preserve only part of the topology of an observed network are systematically used as fundamental null models. However, their generation is still problematic.
Diego Garlaschelli, Tiziano Squartini
core