Results 81 to 90 of about 1,626,050 (291)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

An iterative procedure for obtaining maximum-likelihood estimates of the parameters for a mixture of normal distributions [PDF]

A general iterative procedure is given for determining the consistent maximum likelihood estimates of normal distributions. In addition, a local maximum of the log-likelihood function, Newtons's method, a method of scoring, and modifications of these ...
Peters, B. C., Jr., Walker, H. F.
core   +1 more source

Hedged maximum likelihood estimation

, 2010
This paper proposes and analyzes a new method for quantum state estimation, called hedged maximum likelihood (HMLE). HMLE is a quantum version of Lidstone's Law, also known as the "add beta" rule.
Blume-Kohout, Robin
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Investigating intuitive and deliberate processes statistically: The multiple-measure maximum likelihood strategy classification method

Judgment and Decision Making, 2009
One of the core challenges of decision research is to identify individuals’ decision strategies without influencing decision behavior by the method used.
Andreas Glöckner
doaj   +1 more source

A note on forecasting demand using the multivariate exponential smoothing framework

, 2014
Simple exponential smoothing is widely used in forecasting economic time series. This is because it is quick to compute and it generally delivers accurate forecasts.
Poloni, Federico, Sbrana, Giacomo
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Comparison between Linear Regression and Robust Regression Models by Using Error Criteria and Information Criteria Applied to Human Sample

Zanco Journal of Humanity Sciences
Hypertension is a common and serious disease, and for this reason, a sample of patients was chosen from Azadi Teaching Hospital in Duhok. In this study a comparison was made between Ordinary Least Squares (OLS) with two robust methods Least Trimmed ...
Ismat Mousa Ibrahim
doaj   +1 more source

A maximum-likelihood method to estimate haplotype frequencies and prevalence alongside multiplicity of infection from SNP data. [PDF]

Front Epidemiol, 2022
Tsoungui Obama HCJ, Schneider KA.
europepmc   +1 more source