Results 31 to 40 of about 3,605,812 (301)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Improving the Minimum Free Energy Principle to the Maximum Information Efficiency Principle
EntropyFriston proposed the Minimum Free Energy Principle (FEP) based on the Variational Bayesian (VB) method. This principle emphasizes that the brain and behavior coordinate with the environment, promoting self-organization. However, it has a theoretical flaw,
Chenguang Lu
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Second-order maximum principle controlled weakly singular Volterra integral equations [PDF]
Archives of Control SciencesThis work studies a class of singular Volterra integral equations that are (controlled) and can be applied to memory-related problems. For optimum controls, we prove a second-order Pontryagin type maximal principle.
Jasarat J. Gasimov, Nazim I. Mahmudov
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Twin positive solutions for resonant singular (p,q)-equations
Electronic Journal of Differential Equations, 2021 We consider a Dirichlet (p,q)-equation with a reaction having the combined effects of a singular term and of a resonant perturbation. Using an auxiliary problem to bypass the singularity and variational tools from critical point theory, with truncation ...
Florin I. Onete +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hopf maximum principle revisited
Electronic Journal of Differential Equations, 2015 A weak version of Hopf maximum principle for elliptic equations in divergence form $$ \sum_{i,j=1}^N\partial_i(a_{ij}(x)\partial_ju)=0 $$ with Holder continuous coefficients $a_{ij}$ was shown in [3], in the two-dimensional case.
Jose C. Sabina de Lis
doaj
, 2014 International audienceThe stochastic maximum principle (SMP) gives some necessary conditions for optimality for a stochastic optimal control problem. We give a summary of well-known results concerning stochastic maximum principle in finite-dimensional ...
Ying Hu, Hu, Ying
core +1 more source
The positive maximum principle on symmetric spaces [PDF]
, 2020 We investigate the Courrège theorem in the context of linear operators that satisfy the positive maximum principle on a space of continuous functions over a symmetric space. Applications are given to Feller–Markov processes.
Le Ngan, T., Applebaum, D.
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source