Results 51 to 60 of about 7,132,105 (326)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Stochastic global maximum principle for optimization with recursive utilities

, 2017
In this paper, we study the recursive stochastic optimal control problems. The control domain does not need to be convex, and the generator of the backward stochastic differential equation can contain z.
Mingshang Hu
semanticscholar   +1 more source

A stochastic maximum principle via Malliavin calculus [PDF]

, 2008
This paper considers a controlled It\^o-L\'evy process where the information available to the controller is possibly less than the overall information.
Meyer-Brandis, Thilo, Oksendal, Bernt, Zhou, Xunyu   +2 more
core   +1 more source

Mutation-Selection Balance: Ancestry, Load, and Maximum Principle

, 2002
We show how concepts from statistical physics, such as order parameter, thermodynamic limit, and quantum phase transition, translate into biological concepts in mutation-selection models for sequence evolution and can be used there.
Baake, Baake, Baake, Barton, Boerlijst, Bonhoeffer, Bürger, Bürger, Bürger, Bürger, Charlesworth, Crow, Crow, Demetrius, Demetrius, Eigen, Eigen, Eigen, Ellen Baake, Ethier, Ewens, Franz, Gabriel, Gabriel, Gillespie, Haldane, Hermisson, Higgs, Hofbauer, Hofbauer, Holger Wagner, Huynen, Jagers, Joachim Hermisson, Karlin, Karlin, Kauffman, Kauffman, Kesten, Kimura, Kimura, Kondrashov, Kondrashov, Leuthäusser, Leuthäusser, Maynard Smith, Moran, Nowak, O'Brien, Ohta, Ohta, Oliver Redner, Otto, Phillips, Sniegowski, Swetina, Swofford, Tarazona, Taylor, Wagner, Wagner, Wagner, Waxman, Wiehe, Wilkinson   +64 more
core   +1 more source

The strong maximum principle revisited

Journal of Differential Equations, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
PUCCI, Patrizia, J. SERRIN
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Second-order maximum principle controlled weakly singular Volterra integral equations [PDF]

Archives of Control Sciences
This work studies a class of singular Volterra integral equations that are (controlled) and can be applied to memory-related problems. For optimum controls, we prove a second-order Pontryagin type maximal principle.
Jasarat J. Gasimov, Nazim I. Mahmudov
doaj   +1 more source

A family of degenerate elliptic operators: Maximum principle and its consequences [PDF]

, 2016
In this paper we investigate the validity and the consequences of the maximum principle for degenerate elliptic operators whose higher order term is the sum of k eigenvalues of the Hessian.
I. Birindelli, G. Galise, H. Ishii
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hopf maximum principle revisited

Electronic Journal of Differential Equations, 2015
A weak version of Hopf maximum principle for elliptic equations in divergence form $$ \sum_{i,j=1}^N\partial_i(a_{ij}(x)\partial_ju)=0 $$ with Holder continuous coefficients $a_{ij}$ was shown in [3], in the two-dimensional case.
Jose C. Sabina de Lis
doaj