Results 71 to 80 of about 5,329,290 (309)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Optimal Control of Polymer Flooding Based on Maximum Principle
Journal of Applied Mathematics, 2012 Polymer flooding is one of the most important technologies for enhanced oil recovery (EOR). In this paper, an optimal control model of distributed parameter systems (DPSs) for polymer injection strategies is established, which involves the performance ...
Yang Lei +4 more
doaj +1 more source
A Clustering Method Based on the Maximum Entropy Principle
Entropy, 2015 Clustering is an unsupervised process to determine which unlabeled objects in a set share interesting properties. The objects are grouped into k subsets (clusters) whose elements optimize a proximity measure.
Edwin Aldana-Bobadilla +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Maximum principle and the fourth order boundary value problem
Mathematical Modelling and Analysis, 2011 This paper is devoted to the study the nonlinear boundary value problem . We state a maximum principle related with the operator and apply it to prove the existence and approximation of solutions to the problem (i), (ii), in presence of properly ordered
Inara Yermachenko
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Maximum Principle for Optimal Control Problems with Time Delays
SIAM Journal of Control and Optimization, 2017 : In this paper we present necessary conditions for optimal control problems with time delays. The dynamic constraint is formulated as a control delay differential equation, with time delays occuring in both state and control variables.
Andrea Boccia, R. Vinter
semanticscholar +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Strong maximum principle for fractional diffusion equations and an application to an inverse source problem [PDF]
, 2015 The strong maximum principle is a remarkable property of parabolic equations, which is expected to be partly inherited by fractional diffusion equations.
Yikan Liu, W. Rundell, Masahiro Yamamoto
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source