Results 71 to 80 of about 7,132,105 (326)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Kirchhoff's Loop Law and the maximum entropy production principle

, 2004
In contrast to the standard derivation of Kirchhoff's loop law, which invokes electric potential, we show, for the linear planar electric network in a stationary state at the fixed temperature,that loop law can be derived from the maximum entropy ...
D. Halliday, D. Kondepudi, D.E. Johnson, Davor Juretić, F.W. Sears, G. Kirchhoff, H. Ziegler, I. Prigogine, J.C. Maxwell, J.H. Jeans, J.M. Ziman, J.W.S. Rayleigh, M.I. Krasnov, P. Ehrenfest, Paško Županović, R. Swenson, R.C. Dewar, R.P. Feynman, S.R. Caplan, Srećko Botrić   +19 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Maximum Configuration Principle for Driven Systems with Arbitrary Driving

Entropy, 2018
Depending on context, the term entropy is used for a thermodynamic quantity, a measure of available choice, a quantity to measure information, or, in the context of statistical inference, a maximum configuration predictor.
Rudolf Hanel, Stefan Thurner
doaj   +1 more source

Third order maximum-principle-satisfying direct discontinuous Galerkin methods for time dependent convection diffusion equations on unstructured triangular meshes [PDF]

Journal of Computational Physics, 2015
We develop 3rd order maximum-principle-satisfying direct discontinuous Galerkin methods 8,9,19,21 for convection diffusion equations on unstructured triangular mesh.
Zheng Chen, Hongying Huang, Ju'e Yang
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Maximum Error Parallel Detection Method Based on Locality Principle [PDF]

Jisuanji kexue
Floating-point numbers use a finite number of digits to represent infinite real numbers for computation,so floating-point computation is inherently inaccurate,which can be measured by the maximum error.The traditional floating-point maximum error ...
JI Liguang, YANG Hongru, ZHOU Yuchang, CUI Mengqi, HE Haotian, XU Jinchen
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A maximum principle for second order parabolic system

Journal of Numerical Analysis and Approximation Theory, 1976
Not available.
Anton Mureşan
doaj   +2 more sources

The Maximum Principle for Optimal Control Problems with Time Delays

SIAM Journal of Control and Optimization, 2017
: In this paper we present necessary conditions for optimal control problems with time delays. The dynamic constraint is formulated as a control delay differential equation, with time delays occuring in both state and control variables.
Andrea Boccia, R. Vinter
semanticscholar   +1 more source