Results 71 to 80 of about 8,396,712 (346)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Maximum Entropy Production Principle and Linear Irreversible Processes
Entropy, 2010 It is shown that Onsager’s principle of the least dissipation of energy is equivalent to the maximum entropy production principle. It is known that solutions of the linearized Boltzmann equation make extrema of entropy production.
Milan Brumen +5 more
doaj +1 more source
Combining experiments and simulations using the maximum entropy principle. [PDF]
PLoS Computational Biology, 2014 A key component of computational biology is to compare the results of computer modelling with experimental measurements. Despite substantial progress in the models and algorithms used in many areas of computational biology, such comparisons sometimes ...
Wouter Boomsma +2 more
doaj +1 more source
Journal of Optimization Theory and Applications, 2018 We study a stochastic optimal control problem for a delayed Markov regime-switching jump-diffusion model. We establish necessary and sufficient maximum principles under full and partial information for such a system.
E. Savku, G. Weber
semanticscholar +1 more source
A family of degenerate elliptic operators: Maximum principle and its consequences [PDF]
, 2016 In this paper we investigate the validity and the consequences of the maximum principle for degenerate elliptic operators whose higher order term is the sum of k eigenvalues of the Hessian.
I. Birindelli, G. Galise, H. Ishii
semanticscholar +1 more source
Journal of the Australian Mathematical Society, 1979 AbstractLet K be a nonempty compact set in a Hausdorff locally convex space, and F a nonempty family of upper semicontinuous convex-like functions from K into [–∞, ∞). K is partially ordered by F in a natural manner. It is shown among other things that each isotone, upper semicontinuous and convex-like function g: K → [ – ∞, ∞) attains its K-maximum at
openaire +2 more sources
, 2014 International audienceThe stochastic maximum principle (SMP) gives some necessary conditions for optimality for a stochastic optimal control problem. We give a summary of well-known results concerning stochastic maximum principle in finite-dimensional ...
Ying Hu, Hu, Ying
core +1 more source
On the strong maximum principle
, 2020 In this paper we study the strong maximum principle for equations of the form F[u] = H(u, |Du|) where F is either a fully nonlinear elliptic operator or is the p-Laplace operator.Wegive sufficient conditions on H to ensure that the strong maximum ...
Ahmed Mohammed, Antonio Vitolo
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A class of highly degenerate elliptic operators: maximum principle and unusual phenomena
, 2017 We discuss the validity of the maximum principle below the principal eigenvalue for viscosity solutions of the Dirichlet problem in bounded domains $$ {\cal P}^-_{k}(D^2u)+H(x,\nabla u)+\mu u=0\quad\mbox{in}\;\Omega,\quad u=0\quad\mbox{on}\;\partial ...
Galise, Giulio
core +1 more source