Results 21 to 30 of about 358,493 (263)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Maximum principles for a family of nonlocal boundary value problems

open access: yesAdvances in Difference Equations, 2004
We study a family of three-point nonlocal boundary value problems (BVPs) for an nth-order linear forward difference equation. In particular, we obtain a maximum principle and determine sign properties of a corresponding Green function.
Paul W. Eloe
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The effects of nonlinear perturbation terms on comparison principles for the -Laplacian

open access: yesBulletin of Mathematical Sciences
In this paper, we investigate various comparison principles for quasilinear elliptic equations of [Formula: see text]-Laplace type with lower-order terms that depend on the solution and its gradient.
Ahmed Mohammed, Antonio Vitolo
doaj   +1 more source

Some maximum principles for solutions of a class of partial differential equations in Ω⊂ℝn

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2000
We find maximum principles for solutions of semilinear elliptic partial differential equations of the forms: (1) Δ2u+αf(u)=0, α∈ℝ+ and (2) ΔΔu+α(Δu)k+gu=0, α≤0 in some region Ω⊂ℝn.
Mohammad Mujalli Al-Mahameed
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Maximum Principles for Discrete and Semidiscrete Reaction-Diffusion Equation

open access: yesDiscrete Dynamics in Nature and Society, 2015
We study reaction-diffusion equations with a general reaction function f on one-dimensional lattices with continuous or discrete time ux′  (or  Δtux)=k(ux-1-2ux+ux+1)+f(ux), x∈Z.
Petr Stehlík, Jonáš Volek
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Thermodynamic resource theories, non-commutativity and maximum entropy principles

open access: yesNew Journal of Physics, 2017
We discuss some features of thermodynamics in the presence of multiple conserved quantities. We prove a generalisation of Landauer principle illustrating tradeoffs between the erasure costs paid in different ‘currencies’.
Matteo Lostaglio   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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