Results 31 to 40 of about 372,841 (261)
Mixed local and nonlocal elliptic operators: regularity and maximum principles [PDF]
, 2022 We develop a systematic study of the superpositions of elliptic operators with different orders, mixing classical and fractional scenarios. For concreteness, we focus on the sum of the Laplacian and the fractional Laplacian, and we provide structural ...
Dipierro S. +3 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Journal of the Australian Mathematical Society, 1979 AbstractLet K be a nonempty compact set in a Hausdorff locally convex space, and F a nonempty family of upper semicontinuous convex-like functions from K into [–∞, ∞). K is partially ordered by F in a natural manner. It is shown among other things that each isotone, upper semicontinuous and convex-like function g: K → [ – ∞, ∞) attains its K-maximum at
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Maximum principles for viscosity solutions of weakly elliptic equations
, 2019 Maximum principles play an important role in the theory of elliptic equations. In the last decades there have been many contributions related to the development of fully nonlinear equations and viscosity solutions.
Vitolo, Antonio, Antonio Vitolo
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Maximum principles in unbounded Riemannian domains
, 2023 The necessity of a Maximum Principle arises naturally when one is interested in the study of qualitative properties of solutions to partial differential equations.
Bisterzo, Andrea
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Some maximum principles in semilinear elliptic equations
, 1986 We develop maximum principles for functions defined on the solutions to a class of semilinear, second order, uniformly elliptic partial differential equations. These principles are related to recent theorems of Protter and Protter and Weinberger and to a
Philip W. Schaefer
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FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source