Results 101 to 110 of about 11,013,929 (238)

Implementation Plan for Five Total Maximum Daily Loads for Bacteria in Four Austin Streams [PDF]

, 2015
The implementation plan provides an overview of five creeks and precisely details how the Total Maximum Daily Load Team will respond to pollutants in the water.EXECUTIVE SUMMARY: The Texas Commission on Environmental Quality (TCEQ) is required to ...
Improving Austin Streams Coordination Committee
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Stricter regulation boosts exports: the case of Maximum Residue Levels in pesticides [PDF]

, 2014
Constructing an original panel on Maximum Residue Levels (MRLs) in pesticides for 50 countries over 2006-2012, this paper studies the effect of heterogeneity in MRL regulation on bilateral trade.
Foletti, Liliana, Shingal, Anirudh
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting

Characterization of antibody binding epitopes is an important factor in therapeutic drug discovery, as the binding site determines and drives antibody pharmacology and pharmacokinetics.
Peter S. Lee (14627504), Sean M. West (2135743), Arvind Rajpal (324394), Christine Bee (324385), Gavin Dollinger (1550155), Jason M. Hogan (2191837), Susan C. Wong (14627507), Winse H. Morishige (14627510), Gamze Camdere Tapia (14627513), Pavel Strop (37580)   +9 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

EU (revision of) Minimum Residue Level: Potential Effects on Exporting MSMEs [PDF]

, 2018
18p. - Special note: The title of the document should be "EU (revision of) Maximum Residue Level: Potential Effects on Exporting MSMEs" instead of "EU (revision of) Minimum Residue Level: Potential Effects on Exporting MSMEs"The note illustrates the ...
Verité Research
core   +1 more source

Modification of the existing maximum residue level for fluopyram in purslanes

EFSA Journal, 2017
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer CropScience submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue level (MRL) for the active substance fluopyram in purslanes.
Brancato, Alba, Brocca, Daniela, De Lentdecker, Chloe, Erdos, Zoltan, Ferreira, Lucien, Greco, Luna, Janossy, Judit, Jarrah, Samira, Kardassi, Dimitra, Leuschner, Renata, Lythgo, Christopher, Medina, Paula, Miron, Ileana, Molnar, Tunde, Nougadere, Alexandre, Pedersen, Ragnor, Reich, Hermine, Sacchi, Angela, Santos, Miguel, Stanek, Alois, Sturma, Juergen, Tarazona, Jose, Theobald, Anne, Vagenende, Benedicte, Verani, Alessia, Villamar‐Bouza, Laura   +25 more
openaire   +2 more sources