Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies.
Monika Pichla +3 more
wiley +1 more source
Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones [PDF]
, 2015 The pharmacology of novel psychoactive substances is mostly unknown. We evaluated the transporter and receptor interaction profiles of a series of para-(4)-substituted amphetamines and pyrovalerone cathinones.
Hoener, Marius C. +2 more
core +1 more source
Pharmacology of novel psychoactive substances [PDF]
, 2016 This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core +1 more source
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens [PDF]
, 2016 The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD ...
Hoener, Marius C. +3 more
core +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2010 A study was conducted on 22,158 special B prescriptions (notificações B) containing amphetamine-type anorectic drugs or benzodiazepines, obtained from compounding pharmacies or drugstores located in the city of Natal, RN, Brazil.
Solange Aparecida Nappo +3 more
doaj +1 more source
Bedeutung des Neurotoxins MPTP für Ätiologie und Therapie der idiopathischen Parkinsonkrankheit [Significance of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for the etiology and therapy of idiopathic Parkinson disease] [PDF]
, 1989 Exposure of drug addicts to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has caused a Parkinsonian syndrome accompanied by a selective destruction of dopamine containing neurones in the pars compacta of the substantia nigra.
Lange, Klaus W.
core +1 more source
Optimizing outcomes in ADHD treatment: From clinical targets to novel delivery systems [PDF]
, 2016 Our knowledge and understanding of the underlying neurobiology and symptomatic expression of ADHD has advanced dramatically over the past decade. Associated with these advances has been a similar explosion of new treatment options to individualize ...
Anderson, Richard H +1 more
core +2 more sources
Clinical Studies with Mazindol [PDF]
Obesity Research, 1995 AbstractAn anoerxiant, mazindol suppresses food intake by 1)stimulating β‐adrenergic receptors, 2)inhibiting the feeding center and, 3)stimulating the satiety center in the hypothalamus. In Japan, mazindol is available for clinical use. We examined the effects of mazindol on 1) body weight, appetite, and abnormalities of obesity‐related diseases in ...
openaire +2 more sources
Subanesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks [PDF]
, 2014 Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a
A Bifone +77 more
core +1 more source
ClinicsThe aim of this study was to evaluate efficacy and safety of amfepramone, fenproporex and mazindol as a monotherapy for the treatment of obese or overweight patients.
Rosa Camila Lucchetta +6 more
doaj +1 more source