Results 51 to 60 of about 2,496 (195)

Pharmacological profile of novel psychoactive benzofurans [PDF]

, 2015
Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Hoener, Marius C., Kopf, Simone, Liechti, Matthias E., Rickli, Anna   +3 more
core   +1 more source

A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine. [PDF]

, 2015
Addiction to psychostimulants is a major public health problem with no available treatment. Adenosine A2A receptors (A2A R) co-localize with metabotropic glutamate 5 receptors (mGlu5 R) in the striatum and functionally interact to modulate behaviours ...
Adams, Amalric, Bailey, Bailey, Bailey, Bailey, Berke, Brown, Brown, Cabello, Canals, Castane, Chen, Chesworth, Chesworth, Ciruela, Coccurello, Ferre, Ferre, Fink, Franklin, Georgiou, Ghasemzadeh, Golembiowska, Hillion, Kachroo, Kavanagh, Kitchen, Knapp, Kobayashi, Koob, Kuzmin, Ledent, Mark, Metaxas, Metaxas, Narita, Navarro, Poleszak, Popoli, Popoli, Presti, Quarta, Reeves, Robbins, Rodrigues, Rosin, Schiffmann, Shen, Shimazoe, Short, Zanos, Zanos, Zhang   +53 more
core   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

British Journal of Pharmacology, Volume 176, Issue S1, Page S397-S493, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Catriona MH Anderson, Stefan Bröer, Paul Dawson, Bruno Hagenbuch, James R Hammond, Jules Hancox, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, David T Thwaites, Tiziano Verri   +23 more
wiley   +1 more source

MECHANISM OF ACTION OF (−)CATHINONE, A NEW ALKALOID FROM KHAT LEAVES [PDF]

, 2017
A new alkaloid, (−)cathinone, has recently been isolated from khat leaves and has been shown to induce amphetamine-like behavioural effects. The actions of this alkaloid at the cellular level are discussed here and it is concluded that (−)cathinone ...
KALIX, PETER
core  

Valproic Acid Protects Primary Dopamine Neurons from MPP+‐Induced Neurotoxicity: Involvement of GSK3β Phosphorylation by Akt and ERK through the Mitochondrial Intrinsic Apoptotic Pathway

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Valproic acid (VPA), a drug widely used to treat manic disorder and epilepsy, has recently shown neuroprotective effects in several neurological diseases, particularly in Parkinson’s disease (PD). The goal of the present study was to confirm VPA’s dose‐dependent neuroprotective propensities in the MPP+ model of PD in primary dopamine (DA) neurons and ...
Chi Zhang, Xianrui Yuan, Zhongliang Hu, Songlin Liu, Haoyu Li, Ming Wu, Jian Yuan, Zijin Zhao, Jun Su, Xiangyu Wang, Yiwei Liao, Qing Liu, Beom Seok Jeon   +12 more
wiley   +1 more source

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McIntosh, J. Michael, McKinney, Sheri, Miwa, Julie M., Patzlaff, Natalie E., Steele, Andrew D.   +8 more
core  

Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure [PDF]

, 2001
There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure.
Butterworth, Roger, Michalak, Adrianna, Rose, Christopher   +2 more
core   +1 more source

Repeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund’s adjuvant-induced knee arthritis

Journal of Pain Research, 2017
LE Robledo-González,1 A Martínez-Martínez,1 VM Vargas-Muñoz,1 RI Acosta-González,2 R Plancarte-Sánchez,3 M Anaya-Reyes,4 C Fernández del Valle-Laisequilla,5 JG Reyes-García,6 JM Jiménez ...
Robledo-González LE, Martínez-Martínez A, Vargas-Muñoz VM, Acosta-Gonzalez RI, Plancarte-Sánchez R, Anaya-Reyes M, Fernández del Valle-Laisequilla C, Reyes-García JG, Jiménez-Andrade JM   +8 more
doaj  

Fluoxetine: indication of inadequate use [PDF]

, 2009
OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city.
Alves, Décio de Castro, Carlini, Elisaldo Araujo, Franco, Vera Lúcia da Silva, Nappo, Solange Aparecida, Noto, Ana Regina, Sanchez, Zila van der Meer, Santos, Vilmar Ezequiel dos, Silva, Luiz Carlos Franco   +7 more
core   +3 more sources

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder

Drug Design, Development and Therapy, 2014
Eric Konofal,1,2 Wei Zhao,3–5 Cédric Laouénan,5–7 Michel Lecendreux,1,2 Florentia Kaguelidou,3–5 Lila Benadjaoud,4 France Mentré,5–7 Evelyne Jacqz-Aigrain3–51Pediatric Sleep Disorders Center, 2Child
Konofal E, Zhao W, Laouénan C, Lecendreux M, Kaguelidou F, Benadjaoud L, Mentré F, Jacqz-Aigrain E   +7 more
doaj