Results 1 to 10 of about 108,579 (365)

Activity of nacubactam (RG6080/OP0595) combinations against MBL-producing Enterobacteriaceae [PDF]

Journal of Antimicrobial Chemotherapy, 2018
BACKGROUND Diazabicyclooctanes (DBOs) are promising β-lactamase inhibitors. Some, including nacubactam (OP0595/RG6080), also bind PBP2 and have an enhancer effect, allowing activity against Enterobacteriaceae with MBLs, which DBOs do not inhibit.
S. Mushtaq, A. Vickers, N. Woodford, A. Haldimann, D. Livermore   +4 more
semanticscholar   +2 more sources

Genomic Characterization of High-Count MBL Cases Indicates that Early Detection of Driver Mutations and Subclonal Expansion are Predictors of Adverse Clinical Outcome

Leukemia, 2016
High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic expansion of clonal B cells in the peripheral blood without other manifestations of chronic lymphocytic leukemia (CLL).
Santiago Barrio, T. Shanafelt, Juhi Ojha, K. G. Chaffee, Charla R. Secreto, K. M. Kortüm, S. Pathangey, D. L. Van-Dyke, S. Slager, Rafael Fonseca, Neil E Kay, E. Braggio   +11 more
semanticscholar   +3 more sources

Progression and survival of MBL: a screening study of 10 139 individuals

Blood, 2022
Monoclonal B-cell lymphocytosis (MBL) is a common hematological premalignant condition that is understudied in screening cohorts. MBL can be classified into low-count (LC) and high-count (HC) types based on the size of the B-cell clone.
S. Slager, S. Parikh, S. Achenbach, A. Norman, K. Rabe, N. Boddicker, J. Olson, G. Kleinstern, C. Lesnick, T. Call, J. Cerhan, C. Vachon, N. Kay, E. Braggio, C. Hanson, T. Shanafelt   +15 more
semanticscholar   +1 more source

The ambiguous role of mannose-binding lectin (MBL) in human immunity

Open Medicine, 2021
Mannose-binding lectin (MBL) and lectin complement pathway have become targets of increasing clinical interest. Many aspects of MBL have been recently explored, including the structural properties that allow it to distinguish self from non-self/altered ...
Namarta Kalia, J. Singh, M. Kaur
semanticscholar   +1 more source

The MreB-Like Protein Mbl of Streptomyces coelicolor A3(2) Depends on MreB for Proper Localization and Contributes to Spore Wall Synthesis

Journal of Bacteriology, 2011
Andrea Heichlinger, M. Ammelburg, Eva-Maria Kleinschnitz, Annette Latus, I. Maldener, K. Flärdh, W. Wohlleben, G. Muth   +7 more
semanticscholar   +3 more sources

Phenotypic Tests for Detecting Incidence of Metallo-Β-Lactamase (Mbl) Producing Pseudomonas aeruginosa in Jaipur [PDF]

National Journal of Laboratory Medicine, 2014
Background: Metallo-beta-lactamase (MBL) mediated resistance to carbapenems is an emerging threat in hospital isolates of Pseudomonas aeruginosa.Prompt detection and recognition of MBLs is important for timely implementation of infection control ...
Smita Sood
doaj   +1 more source

فراوانی ژن‌های متالوبتالاکتاماز و بتالاکتامازهای طیف گسترده در باکتری‌های گرم منفی جدا شده از پنومونی وابسته به ونتیلاتور در بخش مراقبت‌های ویژه بیمارستان امام رضا(ع) شهر کرمانشاه [PDF]

مجله دانشکده پزشکی اصفهان, 2023
مقاله پژوهشیمقدمه: پنومونی وابسته به ونتیلاتور، شایع‌ترین عفونت اکتسابی بیمارستانی است که مسؤول افزایش مرگ و میر بیماران بستری در بخش مراقبت‌های ویژه است.
سپیده کدیوریان, ژاله مرادی, محسن نجفی, محسن عزیزی, رامین عبیری, سارا کوتی, امیرهوشنگ الوندی   +6 more
doaj   +1 more source

An Increasing Trend in the Antimicrobial Resistance of Bacterial Isolates from Skin and Soft Tissue Infections in a Tertiary Care Hospital

Journal of Pure and Applied Microbiology, 2021
Skin and soft tissue infections (SSTIs) are commonly occurring infections with mild to serious clinical manifestations. The incidence of wound sepsis in India ranges from 10-33%1,2. It is important to know the potential microbial pathogens causing wound
V Sheeba, Dillirani Vedachalam, T Fahad Affan   +2 more
doaj   +1 more source

Phenotypic and genotypic investigation of metallo-β-lactamases in Pseudomonas aeruginosa clinical isolates in Bushehr, Iran [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Production of metallo-β-lactamases (MBLs) is an important mechanism of resistance to carbapenems. This study aimed to detect the MBL-producing Pseudomonas aeruginosa clinical isolates and to investigate the presence of blaVIM, blaIMP ...
Mahboubeh Seyedi, Forough Yousefi, Behrouz Naeimi, Saeed Tajbakhsh   +3 more
doaj   +1 more source

Antibiotic Adjuvant Therapy for Multi-Drug Resistant Carbapenemases Producing Klebsiella pneumoniae Associated Sepsis: A Case Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Rising resistance and spread of K. pneumoniae strains, create great concerns in treating sepsis patients due to high incidence of mortality and morbidity.
Robin Gupta
doaj   +1 more source