Results 211 to 220 of about 55,808 (260)

Marginal Bone Loss Around Bone-Level Fully Guided Implants With Direct Implant Connection Versus Intermediate Abutment: A Randomized Clinical Trial. [PDF]

open access: yesClin Oral Implants Res
Gargallo-Albiol J   +5 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du   +9 more
wiley   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu   +20 more
wiley   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

open access: yesAdvanced Science, Volume 13, Issue 53, 24 September 2026.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang   +27 more
wiley   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

open access: yesAdvanced Science, Volume 13, Issue 53, 24 September 2026.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong   +16 more
wiley   +1 more source

Dental Implants in Patients with Functional Diversity Under a Strict Prevention Protocol: A Retrospective Pilot Study. [PDF]

open access: yesJ Clin Med
Silvestre-Rangil J   +5 more
europepmc   +1 more source

Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers

open access: yesAlzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross‐sectional abnormalities and longitudinal connectivity changes across clinical stages.
Liwen Zhang   +23 more
wiley   +1 more source

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