Results 81 to 90 of about 108,579 (365)

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions

Environmental Research Letters, 2021
Concern over the ecological damage of excess nitrogen has brought increased attention to the role of research institutions and universities in contributing to this problem.
Sarah Messenger, Javier Lloret, James N Galloway, Anne Giblin   +3 more
doaj   +1 more source

A Floquet Model for the Many-Body Localization Transition

, 2016
The nature of the dynamical quantum phase transition between the many-body localized (MBL) phase and the thermal phase remains an open question, and one line of attack on this problem is to explore this transition numerically in finite-size systems.
Huse, David A., Khemani, Vedika, Zhang, Liangsheng   +2 more
core   +1 more source

#MarielleVive y el MBL

Virtualis, 2022
Este artículo analiza algunos de los espacios digitales del Movimento Brasil Livre (MBL), uno de los representantes de la llamada “nueva derecha” brasileña, centrándose en las acciones del grupo en la proliferación de noticias falsas con motivo del asesinato de la política brasileña Marielle Franco en marzo de 2018.
openaire   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Transition to a many-body localized regime in a two-dimensional disordered quantum dimer model

, 2020
Many-body localization is a unique physical phenomenon driven by interactions and disorder for which a quantum system can evade thermalization. While the existence of a many-body localized phase is now well-established in one-dimensional systems, its ...
Alet, Fabien, Lan, Zhihao, Meyer, Gabriel, Théveniaut, Hugo   +3 more
core   +3 more sources

Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection [PDF]

, 2005
Little is known about the innate immune response to severe acute respiratory syndrome (SARS) coronavirus (CoV) infection. Mannose-binding lectin (MBL), a key molecule in innate immunity, functions as an ante-antibody before the specific antibody response.
Chan, EYT, Chow, EY, Ip, WKE, Jensenius, JC, Ka, LA, Kong, EKP, Kwok, HC, Law, HKW, Lim, W, Peiris, JSM, Tso, GHW, Turner, MW, Wong, WHS, Yu, LL, Yuk, FT, Yung, RWH   +15 more
core   +1 more source

Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2 [PDF]

The Journal of Immunology, 2000
Abstract Mannan-binding lectin (MBL) plays a pivotal role in innate immunity by activating complement after binding carbohydrate moieties on pathogenic bacteria and viruses. Structural similarities shared by MBL and C1 complexes and by the MBL- and C1q-associated serine proteases, MBL-associated serine protease (MASP)-1 and MASP-2, and ...
Vorup-Jensen, T, Petersen, Steen Vang, Hansen, A G, Poulsen, Knud, Schwaeble, W, Sim, R B, Reid, K B, Davis, S J, Thiel, S, Jensenius, J C   +9 more
openaire   +3 more sources

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)*

Journal of Biological Chemistry, 2012
Background: MAP-1 is a novel member of the lectin complement pathway. Results: We present the crystal structure of MAP-1 and show that it inhibits central complement factors and interacts with MBL and ficolin at nm affinities. Conclusion: MAP-1 is a Ca2+-
M. Skjoedt, P. Roversi, T. Hummelshøj, Y. Palarasah, A. Rosbjerg, Steven Johnson, S. Lea, P. Garred   +7 more
semanticscholar   +1 more source