Results 51 to 60 of about 481,129 (243)

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

OncoImmunology, 2018
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno   +16 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Etude de la cellule de commutation d’une alimentation à découpage dans le cadre de la compatibilité électromagnétique

Revue des Énergies Renouvelables, 2014
La Compatibilité Electromagnétique, CEM, apparaît aujourd’hui comme l’une des contraintes majeures de la conception des structures de l’électronique de puissance et plus précisément sur les alimentations à découpage.
A. Lakrim, D. Tahri
doaj  

Influenza virus and endothelial cells: a species specific relationship

Frontiers in Microbiology, 2014
Influenza A virus infection is an important cause of respiratory disease in humans. The original reservoirs of influenza A virus are wild waterfowl and shorebirds, where virus infection causes limited, if any, disease.
Kirsty Renfree Short, Kirsty Renfree Short, Edwin eVeldhuis Kroeze, Leslie A Reperant, Mathilde eRichard, Thijs eKuiken   +5 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Older age relates to worsening of fine motor skills: a population-based study of middle-aged and elderly persons

Frontiers in Aging Neuroscience, 2014
Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test.
Yoo Young eHoogendam, Yoo Young eHoogendam, Fedde evan der Lijn, Fedde evan der Lijn, Meike W eVernooij, Meike W eVernooij, Albert eHofman, Wiro J eNiessen, Wiro J eNiessen, Wiro J eNiessen, Aad evan der Lugt, M Arfan eIkram, M Arfan eIkram, M Arfan eIkram, Jos N evan der Geest   +14 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

In Search of Biomarkers in Eosinophilic Oesophagitis: We are not There Yet!

European Medical Journal Allergy & Immunology, 2016
Background: Eosiniphilic oesophagitis (EoE) is an immune-mediated disease with a complex pathophysiology. The accepted standard for objectively monitoring inflammation associated with this disorder is the number of eosinophils in oesophageal tissue ...
Neeti Bhardwaj, Gisoo Ghaffari
doaj  

Cryo-Gel embedding compound for renal biopsy biobanking

Scientific Reports, 2019
Optimal preservation and biobanking of renal tissue is vital for good diagnostics and subsequent research. Optimal cutting temperature (OCT) compound is a commonly used embedding medium for freezing tissue samples. However, due to interfering polymers in
Malou L. H. Snijders, Marina Zajec, Laurens A. J. Walter, Remco M. A. A. de Louw, Monique H. A. Oomen, Shazia Arshad, Thierry P. P. van den Bosch, Lennard J. M. Dekker, Michail Doukas, Theo M. Luider, Peter H. J. Riegman, Folkert J. van Kemenade, Marian C. Clahsen-van Groningen   +12 more
doaj   +1 more source

The relation between deprivation and healthcare costs in early childhood

International Journal of Integrated Care, 2019
Introduction: One of the most detrimental factors influencing development is growing up in poverty. According to the World Health Organization, extreme poverty is the leading cause of mortality and morbidity.
Marije van der Hulst, Suzanne Polinder, Rianne Kok, Peter Prinzie, Marijke W. de Groot, Eric A.P. Steegers, Loes C.M. Bertens   +6 more
doaj   +1 more source