Results 71 to 80 of about 989,555 (231)

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

OncoImmunology, 2018
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno   +16 more
doaj   +1 more source

The relation between deprivation and healthcare costs in early childhood

International Journal of Integrated Care, 2019
Introduction: One of the most detrimental factors influencing development is growing up in poverty. According to the World Health Organization, extreme poverty is the leading cause of mortality and morbidity.
Marije van der Hulst, Suzanne Polinder, Rianne Kok, Peter Prinzie, Marijke W. de Groot, Eric A.P. Steegers, Loes C.M. Bertens   +6 more
doaj   +1 more source

Comet Mc Naught –Gallery 1

, 2011
Conceptos básicos de la astronomíaEl video muestra varias imágenes del cometa Mc Naught, que fue visible en el cielo del Hemisferio norteComponente Curricular::Educação Superior::Ciências Exatas e da Terra ...
Gimenez, Fernando
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

In Search of Biomarkers in Eosinophilic Oesophagitis: We are not There Yet!

European Medical Journal Allergy & Immunology, 2016
Background: Eosiniphilic oesophagitis (EoE) is an immune-mediated disease with a complex pathophysiology. The accepted standard for objectively monitoring inflammation associated with this disorder is the number of eosinophils in oesophageal tissue ...
Neeti Bhardwaj, Gisoo Ghaffari
doaj  

Influenza virus and endothelial cells: a species specific relationship

Frontiers in Microbiology, 2014
Influenza A virus infection is an important cause of respiratory disease in humans. The original reservoirs of influenza A virus are wild waterfowl and shorebirds, where virus infection causes limited, if any, disease.
Kirsty Renfree Short, Kirsty Renfree Short, Edwin eVeldhuis Kroeze, Leslie A Reperant, Mathilde eRichard, Thijs eKuiken   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Older age relates to worsening of fine motor skills: a population-based study of middle-aged and elderly persons

Frontiers in Aging Neuroscience, 2014
Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test.
Yoo Young eHoogendam, Yoo Young eHoogendam, Fedde evan der Lijn, Fedde evan der Lijn, Meike W eVernooij, Meike W eVernooij, Albert eHofman, Wiro J eNiessen, Wiro J eNiessen, Wiro J eNiessen, Aad evan der Lugt, M Arfan eIkram, M Arfan eIkram, M Arfan eIkram, Jos N evan der Geest   +14 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Sufficient exercise: mother’s perceptions on neighbourhood safety and quality of outdoor playgrounds in Rotterdam

International Journal of Integrated Care, 2019
Introduction: Physical activity in children is associated with both physical and psychological benefits, such as increased cardiorespiratory fitness, reduced body fatness, improved self-esteem and fewer depressive symptoms.
Marije van der Hulst, Loes C.M Bertens, Hanneke de Graaf, Eric A.P. Steegers   +3 more
doaj   +1 more source