Results 61 to 70 of about 496,333 (243)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Sufficient exercise: mother’s perceptions on neighbourhood safety and quality of outdoor playgrounds in Rotterdam

International Journal of Integrated Care, 2019
Introduction: Physical activity in children is associated with both physical and psychological benefits, such as increased cardiorespiratory fitness, reduced body fatness, improved self-esteem and fewer depressive symptoms.
Marije van der Hulst, Loes C.M Bertens, Hanneke de Graaf, Eric A.P. Steegers   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen Family study

Frontiers in Genetics, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies ...
Claudia Tamar Silva, Claudia Tamar Silva, Claudia Tamar Silva, Irina Zorkoltseva, Najaf Amin, Ayse Demirkan, Ayse Demirkan, Elisabeth Maria van Leeuwen, Jan Kors, Marten van den Berg, Bruno Stricker, Bruno Stricker, Bruno Stricker, André Uitterlinden, Anatoly Kirichenko, Jacqueline C.M. Witteman, Rob Willemsen, Ben Oostra, Ben Oostra, Tatiana Axenovich, Cornelia Marja Van Duijn, Cornelia Marja Van Duijn, Aaron Isaacs, Aaron Isaacs   +23 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

“Every MC raps, but not every rapper is an MC”: Examining the MC/Rapper rivalry in American rap music

Volume !, 2022
What’s the difference between the terms “rapper” and “MC”? Do they both describe the same practice? How can their deep-seated rivalry be explained? And how has the symbolic hierarchy between them been established? Through an analysis of the rise (1973-1979) and the economic consolidation of the hip hop movement and of rap music (in the early 1980s ...
openaire   +1 more source

A Dosimetric Comparison Study for Blood Irradiation Employing Different Medium and Algorithms in Clinical Linear Accelerator

Journal of Blood Medicine
Sarath S Nair,1 Jyothi Nagesh,1 Shambhavi C,2 Anshul Singh,1 Shirley Lewis,1 Umesh Velu,1 Deepika Chenna3 1Department of Radiation Oncology, Kasturba Medical College Manipal MAHE, Manipal, Karnataka, India; 2Department of Medical Radiation Physics ...
Nair SS, Nagesh J, C S, Singh A, Lewis S, Velu U, Chenna D   +6 more
doaj  

Cryo-Gel embedding compound for renal biopsy biobanking

Scientific Reports, 2019
Optimal preservation and biobanking of renal tissue is vital for good diagnostics and subsequent research. Optimal cutting temperature (OCT) compound is a commonly used embedding medium for freezing tissue samples. However, due to interfering polymers in
Malou L. H. Snijders, Marina Zajec, Laurens A. J. Walter, Remco M. A. A. de Louw, Monique H. A. Oomen, Shazia Arshad, Thierry P. P. van den Bosch, Lennard J. M. Dekker, Michail Doukas, Theo M. Luider, Peter H. J. Riegman, Folkert J. van Kemenade, Marian C. Clahsen-van Groningen   +12 more
doaj   +1 more source

Enamel matrix derivative has no effect on the chondrogenic differentiation of mesenchymal stem cells

Frontiers in Bioengineering and Biotechnology, 2014
Background: Treatment of large bone defects due to trauma, tumour resection, or congenital abnormalities is challenging. Bone tissue engineering using mesenchymal stem cells (MSCs) represents a promising treatment option.
Lisanne C Groeneveldt, Callie eKnuth, Janneke eWitte-Bouma, Fergal J O'Brien, Eppo B Wolvius, Eric eFarrell   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source