Results 81 to 90 of about 3,526,481 (371)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scientific Reports, 2016 Inflorescence development is a key factor of plant productivity, as it determines flower number. Therefore, understanding the mechanisms that regulate inflorescence architecture is critical for reproductive success and crop yield.
F. Yuste-Lisbona +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Kondo effect in coupled quantum dots under magnetic fields
, 2001 The Kondo effect in coupled quantum dots is investigated theoretically under magnetic fields. We show that the magnetoconductance (MC) illustrates peak structures of the Kondo resonant spectra.
A. C. Hewson +41 more
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
OncoImmunology, 2018 Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou +16 more
doaj +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Revue des Énergies Renouvelables, 2014 La Compatibilité Electromagnétique, CEM, apparaît aujourd’hui comme l’une des contraintes majeures de la conception des structures de l’électronique de puissance et plus précisément sur les alimentations à découpage.
A. Lakrim, D. Tahri
doaj
Frontiers in Aging Neuroscience, 2014 Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test.
Yoo Young eHoogendam +14 more
doaj +1 more source
A test on methods for MC estimation based on earthquake catalog
, 2018 This study tested five methods widely used in estimating the complete magnitudes (MC) of earthquakes. Using catalogs of observed earthquake properties, we test the performance of these five algorithms under several challenging conditions, such as small ...
Yijian Zhou, Shiyong Zhou, J. Zhuang
semanticscholar +1 more source