Results 1 to 10 of about 18,245 (206)

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency [PDF]

Molecular Metabolism, 2017
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg   +27 more
doaj   +6 more sources

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Biomolecules, 2022
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity.
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann   +7 more
doaj   +3 more sources

The role of accessory proteins and co-factors in regulation of melanocortin-4 receptor signalling: An update. [PDF]

J Neuroendocrinol
Abstract The melanocortin‐4 receptor (MC4R) is a G protein‐coupled receptor with an essential role in appetite suppression and energy homeostasis. Genetic mutations in the receptor and components of its signalling pathway that cause obesity in humans, dogs and rodent models have revealed important insights into how the receptor signals and what ...
Jamaluddin A, McClellan A, Raffan E, Gorvin CM.   +3 more
europepmc   +2 more sources

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

International Journal of Molecular Sciences, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +10 more sources

Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis [PDF]

Journal of Neuroinflammation
Astrocytes are key regulators of neuroinflammation in multiple sclerosis (MS). Electroacupuncture (EA), a safe and cost-effective adjuvant therapy, has shown benefits in neurodegenerative diseases, but its astrocyte-related mechanisms remain unclear ...
Yanping Wang, Xiaoru Ma, Zhixin Qiao, Xiyu Zhang, Jiayu Ji, Sifan Zhang, Wei Zhuang, Junfeng Wu, Anqi Li, Chao Wang, Xin Xiu, Jing Wang, Yanting Meng, Wei Huang, Xiujuan Lang, Xijun Liu, Bo Sun, Hulun Li, Yumei Liu   +18 more
doaj   +2 more sources

POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons [PDF]

eLife
Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia Leon, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Victor M Navarro   +11 more
doaj   +2 more sources

MC4R mutant mice develop ovarian teratomas [PDF]

Scientific Reports, 2021
AbstractTeratomas in mice, composed of different tissue types, are derived from primordial germ cells (PGCs) in the foetal gonads. The strongest candidate gene in the testicular teratoma locus (Ter) responsible for testicular teratoma formation was identified as mutation in Dnd1, Dnd1R178*.
Abdullah An Naser, Takehiro Miyazaki, Jun Wang, Shuji Takabayashi, Theeranukul Pachoensuk, Toshinobu Tokumoto   +5 more
openaire   +3 more sources

Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice

Scientific Reports, 2023
Obesity is recognized as an independent risk factor for abdominal aortic aneurysm (AAA). While mutations in the melanocortin-4 receptor (MC4R) gene is the most common cause of obesity caused by mutations in a single gene, the link between MC4R function ...
Kentaro Mori, Hideyuki Okuma, Suguru Nakamura, Hiroyuki Uchinuma, Shigeaki Kaga, Hiroyuki Nakajima, Yoshihiro Ogawa, Kyoichiro Tsuchiya   +7 more
doaj   +1 more source

Melanocortin-4 Receptors (MC4R)

AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023
Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
openaire   +1 more source

The Mc4r gene is responsible for the development of experimentally induced testicular teratomas

Scientific Reports, 2023
Teratomas in mice, composed of different tissue types, are derived from primordial germ cells in the fetal gonads. Previously, we identified a locus responsible for experimental testicular teratoma (ETT) formation on chromosome 18, referred to as ett1 ...
Syunsuke Seki, Kaoru Ohura, Takehiro Miyazaki, Abdullah An Naser, Shuji Takabayashi, Eisei Tsutsumi, Toshinobu Tokumoto   +6 more
doaj   +1 more source