Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis [PDF]
Journal of NeuroinflammationAstrocytes are key regulators of neuroinflammation in multiple sclerosis (MS). Electroacupuncture (EA), a safe and cost-effective adjuvant therapy, has shown benefits in neurodegenerative diseases, but its astrocyte-related mechanisms remain unclear ...
Yanping Wang +18 more
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A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. [PDF]
PLoS ONE, 2012 Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene represent the most frequent cause of monogenic obesity in humans. MC4R mutation analysis in a cohort of 77 children with morbid obesity identified previously unreported heterozygous ...
Susana Granell +6 more
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Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model [PDF]
Cell Reports, 2016 Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD).
Yang Shen +5 more
doaj +2 more sources
Association of the AspP298Asn polymorphism in the MC4R gene with fattening productivity of immunologically castrated and uncastrated gilts [PDF]
Біологія тварин, 2023 The study was aimed at establishing the presence of MC4R (c.1426 A>G) gene polymorphism among the population of immunologically castrated and native gilts (Large White × Landrace) × Maxgro.
Y. Pocherniaieva +2 more
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POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons [PDF]
eLifeInactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi +11 more
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Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety [PDF]
Molecular MetabolismObjective: The melanocortin receptor 4 (MC4R) plays a key role in the CNS regulation of metabolism. In addition to its role within the hypothalamus, other brain areas, including the dorsal raphe nucleus (DRN), express MC4R. However, the identity and role
Satoshi Yamagata +4 more
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Scientific Reports, 2023 Obesity is recognized as an independent risk factor for abdominal aortic aneurysm (AAA). While mutations in the melanocortin-4 receptor (MC4R) gene is the most common cause of obesity caused by mutations in a single gene, the link between MC4R function ...
Kentaro Mori +7 more
doaj +1 more source
The Mc4r gene is responsible for the development of experimentally induced testicular teratomas
Scientific Reports, 2023 Teratomas in mice, composed of different tissue types, are derived from primordial germ cells in the fetal gonads. Previously, we identified a locus responsible for experimental testicular teratoma (ETT) formation on chromosome 18, referred to as ett1 ...
Syunsuke Seki +6 more
doaj +1 more source
Frontiers in Endocrinology, 2020 Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao +7 more
doaj +1 more source
MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)
Biomolecules, 2021 The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R.
Zheng-Yong Wen +6 more
doaj +1 more source