Results 181 to 190 of about 11,016 (204)

MC4R in Central and Peripheral Systems

Advanced Biology, 2023
AbstractObesity has emerged as a critical and urgent health burden during the current global pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in food intake and energy metabolism regulation through various signaling pathways, has been reported to be the lead genetic factor in severe and early onset obesity and ...
Ran Wei, Danjie Li, Sheng Jia, Yuhong Chen, Jiqiu Wang   +4 more
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β-Alanine dipeptides as MC4R agonists

Bioorganic & Medicinal Chemistry Letters, 2003
beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.
Réjean, Ruel, Timothy F, Herpin, Lawrence, Iben, Guanglin, Luo, Alain, Martel, Helen, Mason, Gail, Mattson, Brigitte, Poirier, Edward H, Ruediger, Dan, Shi, Carl, Thibault, Guixue, Yu, Ildiko, Antal Zimanyi, Graham S, Poindexter, John E, Macor   +14 more
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MC4R neurons weigh in differently

Nature Neuroscience, 2006
Food intake and energy expenditure were thought to be simultaneously controlled by the same group of neurons, but now new evidence shows that they are independently regulated by an anatomically distinct set of melanocortin neurons.
Allison W Xu, Gregory S Barsh
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MC4R oligomerizes independently of extracellular cysteine residues

Peptides, 2006
The melanocortin 4 receptor (MC4R) plays an essential role in weight regulation. Recently we could show that the MC4R is able to form receptor dimers. In the present study we investigated the role of extracellular cysteine residues and the structure of the third extracellular loop for receptor dimerization.
Andrea, Elsner, Patrick, Tarnow, Michael, Schaefer, Petra, Ambrugger, Heiko, Krude, Annette, Grüters, Heike, Biebermann   +6 more
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MC4R Agonists: Structural Overview on Antiobesity Therapeutics

Trends in Pharmacological Sciences, 2018
The melanocortin-4 receptor (MC4R) regulates adipose tissue formation and energy homeostasis, and is believed to be a monogenic target for novel antiobesity therapeutics. Several research efforts targeting this receptor have identified potent and selective agonists.
Juliana Pereira Lopes Gonçalves, Daniel Palmer, Morten Meldal   +2 more
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Molecular Genetics of Human Obesity‐Associated MC4R Mutations

Annals of the New York Academy of Sciences, 2003
Abstract: Heterozygous coding mutations in the melanocortin 4 receptor (MC4R) are implicated in 1 to 6% of early onset or severe adult obesity cases. To better address the problem of the genotype:phenotype relationship within this specific form of obesity, we systematically studied the functional characteristics of 50 different obesity‐associated MC4R
Lubrano-Berthelier, Cecile, Cavazos, Martha, Dubern, Beatrice, Shapiro, Astrid, Stunff, Catherine L E, Zhang, Sumei, Picart, Franck, Govaerts, Cedric, Froguel, Philippe, Bougneres, Pierre, Clement, Karine, Vaisse, Christian   +11 more
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β‐Alanine Dipeptides as MC4R Agonists.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Rejean Ruel, et al. et al.
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???????????????????? ???????????????????? ???????????? ?????????????? ?????????? ???????????? ???? ???????????? ESR ???? MC4R

2021
The genetic structure of Large White pigs breed of farm ???Kalityansky Bacon??? fromKiev region was analyzed by genes ESR and MC4R during 2006???2009 years. The frequencyof economically beneficial allele by ESR gene, was fluctuated from 0,32 to 0,59. Thefrequency of economically useful allele of the gene MC4R was fluctuated from 0,50 to 0,70.
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G protein–independent MC4R signaling

Science Signaling, 2015
MC4R controls appetite by modulating potassium channel activity.
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