Results 11 to 20 of about 11,016 (204)

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency [PDF]

Molecular Metabolism, 2017
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg   +27 more
doaj   +6 more sources

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Biomolecules, 2022
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity.
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann   +7 more
doaj   +3 more sources

The Relation between Childhood Obesity and MC4R Gene and Near MC4R Polymorphisms

Gazi Medical Journal, 2019
Childhood obesity, especially in the developed countries including all over the world has an increasing prevalence. Regarding the major impact on public health perspective, childhood obesity should be monitored closely. Many researchers reported MC4R gene and near MC4R region polymorphisms to predispose monogenic obesity both in children and adults. In
Erkal, Ozgur, ERGÜN, MEHMET ALİ, CİNAZ, PEYAMİ, BİDECİ, AYSUN, Boyraz, Mehmet   +4 more
openalex   +3 more sources

MC3R and MC4R Knockdown via RNA Interference

, 2022
Melanocortins (MCs) play an important role in feeding, metabolism, and energy expenditure. While melanocortin receptor (MCR) mRNA has been found in the mesolimbic dopamine (DA) pathway, the ability of melanocortins to regulate feeding and other behaviors through actions on the mesolimbic DA system have not been examined.
Danielle N Mankin
openalex   +3 more sources

MC4R mutant mice develop ovarian teratomas [PDF]

Scientific Reports, 2021
AbstractTeratomas in mice, composed of different tissue types, are derived from primordial germ cells (PGCs) in the foetal gonads. The strongest candidate gene in the testicular teratoma locus (Ter) responsible for testicular teratoma formation was identified as mutation in Dnd1, Dnd1R178*.
Abdullah An Naser, Takehiro Miyazaki, Jun Wang, Shuji Takabayashi, Theeranukul Pachoensuk, Toshinobu Tokumoto   +5 more
openaire   +3 more sources

Melanocortin-4 Receptors (MC4R)

AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023
Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
openaire   +1 more source

Six Years of Genetic Diagnosis of Severe Early-Onset Obesity in a French Cohort. [PDF]

Obes Sci Pract
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
Rama M, Blond E, Janin A, Di-Filippo M, Cuerq C, Marmontel O, Rollat-Farnier PA, Dieterlen E, Segrestin B, Nicolino M, Disse E, Perge K, Collin-Chavagnac D.   +12 more
europepmc   +2 more sources

Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity

iScience, 2020
Summary: In the melanocortin pathway, melanocortin-4 receptor (MC4R) functions to control energy homeostasis. MC4R is expressed in a sub-population of Sim1 neurons (Sim1/MC4R neurons) and functions in hypothalamic paraventricular nuclei (PVN) to control ...
Eugene Nyamugenda, Haven Griffin, Susan Russell, Kimberly A. Cooney, Nicholas S. Kowalczyk, Ishrar Islam, Kevin D. Phelan, Giulia Baldini   +7 more
doaj   +1 more source

Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling

Journal of Sport and Health Science, 2023
Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu, Chao Zhang   +4 more
doaj   +1 more source

Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka

Frontiers in Endocrinology, 2019
In mammals the melanocortin 4 receptor (Mc4r) signaling system has been mainly associated with the regulation of appetite and energy homeostasis. In fish of the genus Xiphophorus (platyfish and swordtails) puberty onset is genetically determined by a ...
Ruiqi Liu, Masato Kinoshita, Mateus C. Adolfi, Manfred Schartl, Manfred Schartl, Manfred Schartl   +5 more
doaj   +1 more source