Results 11 to 20 of about 18,245 (206)
Біологія тварин, 2023 The study was aimed at establishing the presence of MC4R (c.1426 A>G) gene polymorphism among the population of immunologically castrated and native gilts (Large White × Landrace) × Maxgro.
Y. Pocherniaieva +2 more
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Frontiers in Endocrinology, 2020 Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao +7 more
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MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)
Biomolecules, 2021 The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R.
Zheng-Yong Wen +6 more
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Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
iScience, 2020 Summary: In the melanocortin pathway, melanocortin-4 receptor (MC4R) functions to control energy homeostasis. MC4R is expressed in a sub-population of Sim1 neurons (Sim1/MC4R neurons) and functions in hypothalamic paraventricular nuclei (PVN) to control ...
Eugene Nyamugenda +7 more
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Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling
Journal of Sport and Health Science, 2023 Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li +4 more
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Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka
Frontiers in Endocrinology, 2019 In mammals the melanocortin 4 receptor (Mc4r) signaling system has been mainly associated with the regulation of appetite and energy homeostasis. In fish of the genus Xiphophorus (platyfish and swordtails) puberty onset is genetically determined by a ...
Ruiqi Liu +5 more
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Austral Journal of Veterinary Sciences, 2020 To know the genetic situation of the Pampa Rocha, Celta, Bizaro Portuguese, Duroc, Iberian Extremeño and Iberian Andalusian porcine populations, their genetic structure and population dynamics were studied on the IGF2 and MC4R genes, which determine meat
Silvia Llambí +6 more
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Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. [PDF]
PLoS ONE, 2012 Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutations, the most frequent known cause of monogenic obesity, affect the regulation of energy homeostasis.
Marion Valette +5 more
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Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]
, 2007 More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters +34 more
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Cell Regeneration, 2021 Background Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.
Hanqian Xu +6 more
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