Results 191 to 200 of about 11,016 (204)

Attention deficit hyperactivity disorder in obese melanocortin‐4‐receptor (MC4R) deficient subjects: A newly described expression of MC4R deficiency

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2008
AbstractAttention deficit hyperactivity disorder (ADHD) is a heterogeneous highly heritable disorder which has recently been described to be comorbid in obese subjects. This study investigated phenotype/genotype associations in a consanguineous family with genetic obesity due to the melanocortin‐4‐receptor (MC4R) (C271R) mutation.
Anat, Agranat-Meged, Yoad, Ghanadri, Iris, Eisenberg, Ziva, Ben Neriah, Eva, Kieselstein-Gross, Stella, Mitrani-Rosenbaum   +5 more
openaire   +2 more sources

Abstract 5933: Identifying MC4R-targeted small molecule to investigate MC4R impact on cachexia progression

Cancer Research
Abstract Background: The melanocortin system participates in energy homeostasis and appetiteregulation. This metabolic system is primarily located in the central nervous system,specifically in the hypothalamus and brainstem region. Within the melanocortin system,there are five established melanocortin receptors (MCR).
Julia Stokes, Dhanir Tailor, Marie Foss, Benedikt Grau, Sanjay Malhotra   +4 more
openaire   +1 more source

Melanocortin 4 Receptor (MC4R) Deficiency

2018
An 18-year-old female student comes for an evaluation, accompanied by her parents. She has been considering bariatric surgery to manage her long-standing history of obesity. The patient reports that since early childhood, she has had “weight issues.” Her parents remember that at 12 months of age, she was always hungry and constantly seeking food.
openaire   +1 more source

Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity

Journal of Medicinal Chemistry, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi P, Nargund, Alison M, Strack, Tung M, Fong   +2 more
openaire   +2 more sources

?????????? Asp298Asn ???????????????????????? ???????? mc4r ?? ???????????????? ???????????????? ???????? ?? ???????????? ?????????????? ?????????? ????????????

2014
?????????????????????? ?????????? Asp298Asn-???????????????????????? ???????? mc4r c ?????????????????? ???????????? ????????????????, ?????? ?????????????? ???????????????? ???????? ?? ???????????? ?????????????? ?????????? ???????????? ?????????????????? ???? ????????????????????. ???????????????????? ?????????????????? ???????????????????????? ??????
openaire   +1 more source

POMC/MC4R signaling in Alzheimer's disease

2019
Alzheimer’s disease (AD) is the most prevalent form of dementia worldwide. It is characterized by synaptic deficits, excessive β-amyloid (Aβ) accumulation, and hyperphosphorylation of intraneuronal tau protein in brain. However, the mechanisms underlying AD pathology is unclear, and no effective treatment has been developed.
openaire   +2 more sources

Link between MC4R mutations and adiposity

Nature Reviews Endocrinology, 2021
openaire   +2 more sources

Evolutionary Perspective of MC4R

Aktuelle Ernährungsmedizin, 2006
DA Hughes, A Hinney, AK Wermter, J Hebebrand, H Biebermann, M Stoneking   +5 more
openaire   +1 more source

Long-Term MC4R Agonist Treatment in POMC-Deficient Patients

New England Journal of Medicine, 2022
Peter Kühnen, Karine Clément
openaire   +2 more sources

A SNP in the cattle MC4R gene is used to map MC4R to BTA 24

Animal Genetics, 2001
T D, Thue, S M, Schmutz, F C, Buchanan
openaire   +2 more sources