Results 31 to 40 of about 11,016 (204)

Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake [PDF]

Endocrinology and Metabolism, 2015
BackgroundThe melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food in association with a brain reward system, such as ...
Ye Ran Yoon, Ja-Hyun Baik
doaj   +1 more source

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response [PDF]

Journal of Endocrinology, 2010
Human melanocortin 4 receptor (hMC4R) mutations with in vitro functional effects are responsible for 0.5–2.5% of severe obesity. Designing ligands that are able to counteract this in vitro-associated molecular defect is crucial to develop specific anti-obesity drugs in these genetically associated cases.
Pierre, Roubert, Béatrice, Dubern, Pascale, Plas, Cécile, Lubrano-Berthelier, Rohia, Alihi, Florence, Auger, Daniel B, Deoliveira, Jesse Z, Dong, Arnaud, Basdevant, Christophe, Thurieau, Karine, Clément   +10 more
openaire   +2 more sources

Association between MC4R rs17782313 polymorphism and overeating behaviors [PDF]

International Journal of Obesity, 2014
Melanocortins play a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined.
Yilmaz, Z., Davis, C., Loxton, N. J., Kaplan, A. S., Levitan, R. D., Carter, J. C., Kennedy, J. L.   +6 more
openaire   +3 more sources

The Human MC4R Promoter [PDF]

Diabetes, 2003
Heterozygous mutations in the coding sequence of the serpentine melanocortin 4 receptor (MC4R) are the most frequent genetic cause of severe human obesity. Since haploinsufficiency has been proposed as a causal mechanism of obesity associated with these mutations, reduction in gene transcription caused by mutations in the transcriptionally essential ...
Cecile Lubrano-Berthelier, Martha Cavazos, Catherine Le Stunff, Kurt Haas, Astrid Shapiro, Sumei Zhang, Pierre Bougneres, Christian Vaisse   +7 more
openaire   +1 more source

MC4R Gene Polymorphisms Interact With the Urbanized Living Environment on Obesity: Results From the Yi Migrant Study

Frontiers in Genetics, 2022
Objectives: This study aimed to determine the association of MC4R gene polymorphisms (rs17782313 and rs12970134) and urbanized living environment and the gene–environment interaction with obesity in Yi people in China.Methods: A 1:2 frequency-matched ...
Ye Wang, Li Pan, Shaoping Wan, Wuli Yihuo, Fang Yang, Huijing He, Zheng Li, Zhengping Yong, Guangliang Shan   +8 more
doaj   +1 more source

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia [PDF]

International Journal of Molecular Sciences, 2020
The melanocortin receptor 4 (MC4R) signaling system consists of MC4R, MC4R ligands [melanocyte-stimulating hormone (MSH), adrenocorticotropin (ACTH), agouti-related protein (AgRP)], and melanocortin-2 receptor accessory protein 2 (MRAP2), and it has been proposed to play important roles in feeding and growth in vertebrates.
Tianqiang Liu, Yue Deng, Zheng Zhang, Baolong Cao, Jing Li, Caiyun Sun, Zhixing Hu, Jiannan Zhang, Juan Li, Yajun Wang   +9 more
openaire   +2 more sources

Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure

Molecular Metabolism, 2018
Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis. Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity ...
Giuseppe Bruschetta, Jung Dae Kim, Sabrina Diano, Li F. Chan   +3 more
doaj   +1 more source

MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort

Frontiers in Endocrinology, 2020
Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide association studies have identified several MC4R variants associated with adiposity; of these, rs17782313,
Maha M. Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Preethi Cherian, Irina Al Khairi, Motasem Melhem, Fadi Alkayal, Fadi Alkayal, Osama Alsmadi, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker   +11 more
doaj   +1 more source

Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea

JPGN Reports, EarlyView.
Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno, Angelo Corso Faini, Silvia Deaglio, Marianna Pellegrini, Raffaele Buganza, Francesca Giuliani, Pier Luigi Calvo, Michele Pinon   +7 more
wiley   +1 more source