Results 71 to 80 of about 10,319 (179)

Effect of MC4R gene polymorphism on food intake in adolescents with overweight and obesity

Ожирение и метаболизм, 2019
BACKGROUND: The melanocortin 4 receptor gene (MC4R) codes the receptor expressed in the hypothalamus and involved in the regulation of body mass and height.
Kseniya D. Ievleva, Tatyana A. Bairova, Ekaterina A. Sheneman, Varvara V. Balzhieva, Zhanna G. Ayurova, Lubov V. Rychkova, Lubov I. Kolesnikova   +6 more
doaj   +1 more source

Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

Molecular Medicine
Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions.
Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan, Haohao Zhang   +11 more
doaj   +1 more source

In Silico Evaluation of Phaseolus vulgaris Seeds as Appetite-Suppressing Agents via Melanocortin-4 and GLP-1 Receptor Activation [PDF]

BIO Web of Conferences
Childhood obesity is strongly influenced by dysregulated appetite signalling, particularly within pathways involving melanocortin-4 receptor (MC4R) and glucagon-like peptide-1 receptor (GLP-1R). Phaseolus vulgaris has been reported to reduce body weight,
Firzani Nur Auliana, Tilaqza Andri, Amalia Yeni   +2 more
doaj   +1 more source

Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice

Scientific Reports
The onset and progression mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are being studied.
Kyutaro Koyama, Akira Sakamaki, Shinichi Morita, Itsuo Nagayama, Marina Kudo, Yuto Tanaka, Naruhiro Kimura, Yoshihisa Arao, Hiroyuki Abe, Kenya Kamimura, Shuji Terai   +10 more
doaj   +1 more source

MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture

Cells
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor (GPCR) that is expressed in several brain locations encompassing the hypothalamus and the brainstem, where the receptor controls several body functions, including metabolism.
Haven Griffin, Jude Hanson, Kevin D. Phelan, Giulia Baldini   +3 more
doaj   +1 more source

Mice lacking β-arrestin-2 in melanocortin 4 receptor–expressing neurons show marked metabolic deficits

JCI Insight
Hypothalamic melanocortin 4 receptors (MC4Rs) play a central role in regulating food intake and energy homeostasis. In fact, inactivating mutations in the MC4R gene are the most common form of monogenic obesity.
Misbah Rashid, Lei Wang, Zhenzhong Cui, Oksana Gavrilova, Huiyan Lu, Kozo Kaibuchi, Sarah Zeitlmayr, Thomas Gudermann, Andreas Breit, Jürgen Wess   +9 more
doaj   +1 more source

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

eLife
Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment.
Conor J Howard, Nathan S Abell, Beatriz A Osuna, Eric M Jones, Leon Y Chan, Henry Chan, Dean R Artis, Jonathan B Asfaha, Joshua S Bloom, Aaron R Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A Uribe, Sriram Kosuri, Diane E Dickel, Nathan B Lubock   +17 more
doaj   +1 more source

A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice

The Journal of Clinical Investigation
Melanocortin 4 receptor (MC4R) mutations are the most common cause of human monogenic obesity and are associated with hyperphagia and increased linear growth.
Peter J. Metzger, Aileen Zhang, Bradley A. Carlson, Hui Sun, Zhenzhong Cui, Yongqi Li, Marshal T. Jahnke, Daniel R. Layton, Meenakshi B. Gupta, Naili Liu, Evi Kostenis, Oksana Gavrilova, Min Chen, Lee S. Weinstein   +13 more
doaj   +1 more source

MC4R Gene [PDF]

, 2020
openaire   +1 more source

Missense variants in MC4R gene are associated with obesity in cats

Veterinary Research Communications
Abstract Obesity stands out as the most common multifactorial nutritional problem affecting domestic cats. According to studies, the prevalence of overweight or obese cats varies between 11.5% and 63%. Various factors such as breed, age, gender, reproductive status, owner-pet relationship, diet type, and environmental factors have been ...
Salah Aldin Mousa Basha, Iraz Akis
openaire   +2 more sources