Results 141 to 150 of about 3,703 (248)

Common variation in meiosis genes shapes human recombination and aneuploidy. [PDF]

Nature
Carioscia SA, Biddanda A, Starostik MR, Tang X, Hoffmann ER, Demko ZP, McCoy RC.   +6 more
europepmc   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface-enhanced Raman Spectroscopy. [PDF]

Adv Sci (Weinh)
Aljuhani W, Zhang Y, Wylie MP, McCoy CP, Bell SEJ.   +4 more
europepmc   +1 more source

Bouffant: La Teuer de Vampires

, 2013
Received from the Theatre Department and edited by Leerin Campbell, Class of 2015, in 2013.A scene from Bouffant: La Teuer de Vampires with Chase ...

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Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Use of hydrophilic pharmaceutical excipients to modulate release of metal ions from silicone elastomers. [PDF]

Drug Deliv
Shen X, Zhao X, McCoy CF, Dallal Bashi YH, Boyd P, Malcolm RK.   +5 more
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Characterization of the cell division-associated peptidoglycan amidase AmiA of <i>Chlamydia trachomatis</i>. [PDF]

J Bacteriol
Dannenberg J, Lee J, Liechti GW, Otten C, Löckener I, Reuter J, Klöckner A, Krannich S, Schneider T, Ouellette SP, Henrichfreise B.   +10 more
europepmc   +1 more source

Hydraulic Geometry of Debris-Flow Channel Networks With Implications for Discharge Estimation

In steep landscapes, debris flows scour much of the upper channel network and significantly alter longitudinal profile form at drainage areas less than 1 to 5 km². The degree to which debris-flow processes alter other aspects of the upper channel network
Ring, Caleb M.
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