Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson +18 more
wiley +1 more source
Cefdinir binding to a class A β-lactamase revealed by serial cryo-crystallography. [PDF]
Gore G +4 more
europepmc +1 more source
Vanadium Isotopic Compositions of the High‐3He/4He Baffin Island Lavas
Abstract The isotopic composition of vanadium (V) in hotspot lavas provides new insight into the source of deep mantle heterogeneities. We measured V isotopic compositions in Paleogene Baffin Island lavas, which erupted above the Iceland plume head, to constrain the mantle plume source. These lavas have V isotopic compositions that are lighter (−0.96 ±
Jonas Kaare‐Rasmussen +4 more
wiley +1 more source
Basal Force Probability Distributions in Thin‐Layer Granular Flows
Abstract Extreme geophysical flows, such as granular and debris flows, can significantly shape the landscape in steep lands and generate seismic signals that can be recorded over long distances. However, direct field measurements needed to constrain the granular physics remain difficult due to the damage potential of those flows.
Jun Fang +5 more
wiley +1 more source
Comparison of 2D, 3D <i>In Vitro</i>, and <i>Ex Vivo</i> Platforms for Modeling the Rat Small Intestine. [PDF]
Elias-Kirma S +7 more
europepmc +1 more source
Automated Mineral Identification and Rock‐Type Classification of Lunar Mare Basalts Using SEM Images
Abstract We present an automated system for identifying minerals and classifying rock types in Apollo lunar mare basalts using scanning electron microscopy (SEM) imagery. Mineral segmentation is based on a U‐Net architecture, supplemented by two scale‐aware models designed to incorporate pixel size information.
Ji‐In Jung +3 more
wiley +1 more source
Bridging mechanism and design: modern medicinal chemistry approaches to thymidylate synthase inhibitors. [PDF]
Al-Karmalawy AA +4 more
europepmc +1 more source
Abstract Iron meteorites provide insight into the formation processes of planetary cores from the early Solar System. Through further classifying individual irons into specific groups, which are assumed to represent a common parent body, greater information can be yielded into the formation processes of those bodies.
A. F. Rogers +4 more
wiley +1 more source
Active maintenance of meiosis-specific chromosome structures in <i>Caenorhabditis elegans</i> by the deubiquitinase DUO-1. [PDF]
Strand LG +5 more
europepmc +1 more source
Abstract Enstatite chondrites record highly reducing conditions in the early solar nebula, yet the origin of their abundant sulfides remains unclear. Niningerite (MgS) and oldhamite (CaS) are ubiquitous in EH3 enstatite chondrites and distinguish them from other chondrite groups.
N. Imae
wiley +1 more source

