Results 141 to 150 of about 148,261 (178)
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2018
Homeothermy represents a remarkable step in animal evolution, albeit at a very high cost in terms of metabolic demand. The maintenance of core body temperature in mammals represents one of the prominent physiological components contributing to the basal metabolic rate.
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Homeothermy represents a remarkable step in animal evolution, albeit at a very high cost in terms of metabolic demand. The maintenance of core body temperature in mammals represents one of the prominent physiological components contributing to the basal metabolic rate.
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Tetrahydroisoquinolines as MCH-R1 antagonists
Bioorganic & Medicinal Chemistry Letters, 2006A series of potent and selective inhibitors of h-MCH-R1 has been developed based on the piperidine glycineamide compounds I and II. These structurally more rigid tetrahydroisoquinolines (III and IV) showed better pharmacokinetics. The highly potent compounds 12d and 12g displayed excellent rat pk.
T K, Sasikumar +8 more
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Ontogenetic development of the diencephalic MCH neurons: a hypothalamic ‘MCH area’ hypothesis
European Journal of Neuroscience, 2001AbstractThe ontogeny of rat diencephalic melanin‐concentrating hormone (MCH) neurons has been analysed, using the bromodeoxyuridine method to determine the period of birth of these neurons, and using in situ hybridization and immunohistochemistry to study their chemical differentiation.
F, Brischoux, D, Fellmann, P Y, Risold
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Melanin concentrating hormone (MCH): Synthesis and bioactivity studies of MCH fragment analogues
Peptides, 1989Nineteen analogues of melanin concentrating hormone (MCH) were synthesized and tested for their skin-lightening activities in the in vitro eel skin (Synbranchus marmoratus) bioassay. All the analogues synthesized were fragments of the native sequence: Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val with sequential elimination of ...
T O, Matsunaga +3 more
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2018
Depression is a mood disorder affecting emotional, somatic, and cognitive domains. The efficacy of the antidepressant therapies is generally acceptable; however, unpleasant or adverse effects, delayed onset of action, and unresponsive patients continue to be the most common problem in the psychiatric practice.
Jessika Urbanavicius +4 more
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Depression is a mood disorder affecting emotional, somatic, and cognitive domains. The efficacy of the antidepressant therapies is generally acceptable; however, unpleasant or adverse effects, delayed onset of action, and unresponsive patients continue to be the most common problem in the psychiatric practice.
Jessika Urbanavicius +4 more
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Characterization of [Phe13, Tyr19]-MCH analog binding activity to the MCH receptor
Neuropeptides, 2000Melanin concentrating hormone (MCH), a hypothalamic neuropeptide, is an important regulator of energy homeostasis in mammals. Characterization of an MCH specific receptor has been hampered by the lack of a suitable radioligand. The [Phe(13), Tyr(19)]-MCH analog has been shown by different investigators to bind specifically to cell lines of epithelial ...
E, Kokkotou +7 more
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Maternal and Child Health Journal, 2007
Leadership in Maternal and Child Health (MCH) requires a repertoire of skills that transcend clinical or academic disciplines. This is especially true today as leaders in academic, government and private settings alike must respond to a rapidly changing health environment.
Wendy E, Mouradian, Colleen E, Huebner
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Leadership in Maternal and Child Health (MCH) requires a repertoire of skills that transcend clinical or academic disciplines. This is especially true today as leaders in academic, government and private settings alike must respond to a rapidly changing health environment.
Wendy E, Mouradian, Colleen E, Huebner
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Identification and Characterization of Single‐Nucleotide Polymorphisms in MCH‐R1 and MCH‐R2*
Obesity Research, 2004AbstractObjective: To identify and functionally characterize single‐nucleotide polymorphisms (SNPs) in melanin‐concentrating hormone (MCH)‐R1 and ‐R2.Research Methods and Procedures: The entire coding regions and intron/exon splice junction regions ofMCH‐R1andMCH‐R2were sequenced from anonymous white (n= 45) and African‐American (n= 46) individuals ...
Brian E, Hawes +6 more
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2015
The marine sediment metagenome samples are used for the research of Bioremediation of Southern Mediterranean oil polluted sites comes of age .
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The marine sediment metagenome samples are used for the research of Bioremediation of Southern Mediterranean oil polluted sites comes of age .
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