Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
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Cloning and Characterization of Rhesus Monkey MCH-R1 and MCH-R2
Peptides, 2002Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues.
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Identification and Characterization of Single-Nucleotide Polymorphisms in MCH-R1 and MCH-R2
Obesity, 2004AbstractObjective: To identify and functionally characterize single‐nucleotide polymorphisms (SNPs) in melanin‐concentrating hormone (MCH)‐R1 and ‐R2.Research Methods and Procedures: The entire coding regions and intron/exon splice junction regions ofMCH‐R1andMCH‐R2were sequenced from anonymous white (n= 45) and African‐American (n= 46) individuals ...
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MCH Neurons Regulate Permeability of the Median Eminence Barrier [PDF]
Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels ...
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