Results 81 to 90 of about 78,177 (302)

Complement Activation Linked to Type II Interferon Signaling in Still Disease

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory syndrome characterized by innate immune dysregulation. Although complement can drive inflammation, its involvement in SD remains to be defined. Thus, we aimed to assess complement activation in SD. Methods Complement was assessed using transcriptomic, proteomic, and in vitro approaches. RNA sequencing
Freya M. C. H. Huijsmans, Tabea Thalheim, Alejandra Bodelón, Greta Rogani, Lyanne J. P. M. Sijbers, Remco G. A. Erkens, Aafke de Ligt, Rianne Scholman, Aron Brinker, Gisella B. Beretta, Nienke M. Ter Haar, Thomas Vogl, Johannes Roth, Trang T. Duong, Sytze de Roock, Joost F. Swart, Deborah A. Marshall, Susanne M. Benseler, Rae S. M. Yeung, Christoph Kessel, Sebastiaan J. Vastert, Emely L. Verweyen, Jorg van Loosdregt, on behalf of the UCAN CAN‐DU/UCAN CURE Consortia and the One Child Every Child Initiative, Adam Huber, Bianca Lang, Chelsea DeCoste, Elizabeth Stringer, Suzanne Ramsey, Alan Rosenberg, Kate Neufeld, Mehul Jariwala, Tristan Kerr, Alexander Mosoiu, Alisa Rachlis, Amy Xu, Arthur Cheng, Brenleigh Jebb, Brian Feldman, Bruno Pereira, Deborah Levy, Dilan Dissanayake, Elizaveta Limenis, Evelyn Rozenblyum, Harper Cheng, Jennifer Ji Young Lee, Lynn Spiegel, Rayfel Schneider, Ronald Laxer, Ruud Verstegen, Shirley Tse, Andrea Human, David Cabral, Herman Tam, Jaime Guzman, Kim Morishita, Kristin Houghton, Lori Tucker, Mercedes Chan, Ross Petty, Tommy Gerschman, Annet van Royen‐Kerkhof, Berent Prakken, Erika Van Nieuwenhove, Marc Jansen, Nico Wulffraat, Ciarán Duffy, Nadia Luca, Roman Jurencak, Tala El Tal, Claire LeBlanc, Gaëlle Chédeville, Piya Lahiry, Rosie Scuccimarri, Sarah Campillo, Clare Hutchinson, Daniah Basodan, Dax G Rumsey, Hon Yan Ng, Jeanine McColl, Lillian Lim, Tara McGrath, Danielle Brinkman, Petra Hissink Muller, Elizabeth Legger, Wineke Armbrust, Ellen Schatorje, Esther Hoppenreijs, Elodie Boudes, Gillian Currie, Heinrike Schmeling, Muhammed Dhalla, Nicole Johnson, Paivi Miettunen, Ravneet Sran, Rebeka Stevenson, Erkan Demirkaya, Jonathan Park, Roberta Berard, Giske Biesbroek, Mariken Gruppen, Gordon Soon, Joseph Cafazzo, Liane Heale, Michelle Batthish, Tania Cellucci, Lily Lim, Maarten IJzerman, Marinka Twilt, Marleen Verkaaik, Philomine van Pelt, Sylvia Kamphuis, Michelle Kip, Nicholas Blanchette, Paul Dancey, Regina de Geus   +115 more
wiley   +1 more source

IJCM_44A: Analysis of Health System and Community Readiness for Adhering to Government Guidelines on Gestational Diabetes Mellitus in India

Indian Journal of Community Medicine
Background: GDM affects approximately 7% of all pregnant women worldwide. India has one of the highest prevalence of Diabetes Mellitus in the world. In a field study in Tamil Nadu, the prevalence of GDM was 17.8% in the urban, 13.8% in the semi urban and
Amey Dhatrak
doaj   +1 more source

Caractérisation fonctionnelle du système MCH/MCH-R1 dans des modèles neuronaux et immunitaires (de nouveaux rôles pour la MCH ?)

, 2006
La Melanin-Concentrating Hormone (MCH) est un neuropeptide cyclique de 19 acides aminés chez les mammifères, principalement exprimé au niveau de l hypothalamus, où il est impliqué dans plusieurs fonctions comme la régulation de la prise alimentaire ou l ...
GRAND, Natacha, NAHON, Jean-Louis
core  

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

A clinicopathological investigation on morphological alterations of red blood cells among treated and untreated type II diabetes mellitus patients

Indian Journal of Pathology and Microbiology
Introduction: The cross-sectional study was designed to analyze the morphological changes occurring in red blood cells (RBCs) among patients with type II diabetes mellitus (type II DM) and to investigate the association of these changes with various ...
Madhurima Basak, Surya Kanta Dey, Sourav Ghosh, Dipanjan Bhattacharjee, Arun Nayek, Abhishek Janaa   +5 more
doaj   +1 more source

Exploring the roles of neurons that express melanin-concentrating hormone (MCH) [PDF]

, 2013
Thesis (Ph.D.)--University of Washington, 2013MCH-expressing neurons have been ascribed many roles based on studies of MCH-deficient mice. However, MCH neurons express other neurotransmitters, including GABA, nesfatin and cocaine-amphetamine-regulated ...
Whiddon, Benjamin Barnett
core  

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Analysis of Off-label Use of Intravenous Immunoglobulin in a Tertiary Health Care Facility: A Record-based Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: The off-label clinical use of Intravenous Immunoglobulin (IVIG) has increased despite the existence of its approved indications by drug regulatory agencies.
Mitali Ganapati, Snigdha Rani Panigrahy, Abinash Panda, Jayanti Prava Behera   +3 more
doaj   +1 more source

Characterisation of melanin-concentrating hormone (MCH) receptors

, 2002
L'hormone de mélano-concentration (MCH) a été isolée initialement chez les poissons téléostéens sous la forme d'un peptide de 17 acides aminés. Chez les mammifères c'est un puissant neuropeptide orexigénique produit par des neurones hypothalamiques ...
Schlumberger, Sophie
core  

Engineered immunostimulatory H2O2‐producing microreactors driven by yeast as localized living cancer therapeutics

BMEMat, EarlyView.
Engineered yeast microreactors that produce H2O2 within tumors enable selective cancer cell killing while releasing immunostimulatory components, effectively suppressing local tumor growth and activating systemic antitumor immunity, with further efficacy enhanced by anti‐PD‐1 therapy and transarterial embolization.
Wenqian He, Chunjie Wang, Minming Chen, Weihao Yang, Bin Yu, Yuhang Hu, Hengze Ding, Yifan Yan, Zhijuan Yang, Liangzhu Feng   +9 more
wiley   +1 more source