Results 11 to 20 of about 188,053 (286)

Strength ranking for interfaces between a TiN hard coating and microstructural constituents of high speed steel determined by micromechanical testing

Materials & Design, 2021
Knowledge about the adhesion of protective hard coatings on tool materials is of great importance to understand their failure mechanisms in metalworking.
Matthias Gsellmann, Thomas Klünsner, Christian Mitterer, Martin Krobath, Michael Wurmshuber, Harald Leitner, Werner Ecker, Stefan Marsoner, Verena Maier-Kiener, Daniel Kiener, Gerald Ressel   +10 more
doaj   +1 more source

Simulation and experimental characterization of microporosity during solidification in Sn-Bi alloys

Materials & Design, 2021
The formation of microporosity during solidification of Sn-Bi alloys is investigated through experiments and simulations. Samples of varying composition with 20, 30, 47 and 58 wt% Bi are solidified in a copper mould and the pore fraction is measured ...
Georg Siroky, Elke Kraker, Dietmar Kieslinger, Ernst Kozeschnik, Werner Ecker   +4 more
doaj   +1 more source

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +3 more sources

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung [PDF]

, 2013
Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome,
A Cross, A G Rossi, A Planaguma, AE Leitch, AE Leitch, AG Rossi, AL Alessandri, B Dibbert, BM Fournier, C Akgul, C D Lucas, C Haslett, C Nathan, C T Robb, CD Lucas, CN Serhan, D A Dorward, DA Dorward, DA Moulding, DA Moulding, DA Steimer, DJ Wardle, E Abraham, EE McGrath, GL Bannenberg, GS Worthen, H Liu, HG Folkesson, HM Marriott, I Dzhagalov St, I Nicoletti, J A Marwick, J Liang, JS Savill, K C Allen, K Ganeshan, KP Steinberg, L Fialkow, L Santo, M A Tait, MA Matthay, N Chiang, N Fotouhi-Ardakani, N Hirani, O Eickmeier, R Boxio, R Duffin, S Brode, S Fox, S Fox, S Michlewska, SJ Leuenroth, SL Poe, SP Garrison, T Hideshima, T Tanaka, TR Ulich, U Koedel, Y Liu   +58 more
core   +1 more source

ЕPIDEMIOLOGY OF "O'DONOGHUE'S TRIAD" [PDF]

Journal of IMAB
The term "Unhappy Triad", coined by O'Donoghue, reflects a severe knee injury with rupture of the medial collateral ligament, medial meniscus, and anterior cruciate ligament.
Mariya Gramatikova
doaj   +1 more source

Synthesis, properties, and some rhodium, iridium, and platinum complexes of a series of bulky m-terphenylphosphine ligands [PDF]

, 2016
A series of sterically demanding aryl phosphine ligands (L) bearing terphenyl substituents, PR2Ar′ (R = hydrocarbyl, Ar′ = 2,6-diarylphenyl radical) has been prepared and characterized. The stability of these ligands towards oxidation in the air has been
Campos Manzano, Jesús, Carmona Guzmán, Ernesto, Conejero Iglesias, Salvador, Fernández Espada, María, López Serrano, Joaquín, Maya Díaz, Celia María, Moreno Díaz, Juan José, Navarro Gilabert, Carlos, Ortega Moreno, Laura, Peloso, Riccardo   +9 more
core   +1 more source

Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1) [PDF]

, 2016
Protein–protein interactions (PPIs) control many cellular processes in cancer and tumour growth. Of significant interest is the role PPIs play in regulating apoptosis.
Adams, Andrews, Atwell, Bell, Belmar, Bernardo, Beroukhim, Bruncko, Cominetti, Crow, Czabotar, de Clermont, Du, Friberg, Frumina, Gerrard, Guoan, Huang, Jones, Juin, Keskin, Kitada, Milroy, Nozoe, Perciavalle, Perkin, Petros, Petros, Premnath, Schmid, Takahashi, Tan, Tse, Vousden, Wei, Wertz, Wilson, Yip, Zhou   +38 more
core   +1 more source

Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD+ Binding and the Cofactor Positioned to Accept a Hydride

Scientific Reports, 2017
Plants, lower eukaryotes, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that is absent in mammals. This makes the His biosynthetic route a promising target for herbicides, antifungal agents, and antibiotics ...
Milosz Ruszkowski, Zbigniew Dauter
doaj   +1 more source

Evidence of austenite memory in PH 15-5 and assessment of its formation mechanism

Materials & Design, 2019
Austenite memory and subsequent spontaneous recrystallization during austenitization is stated for some types of soft martensitic stainless steels such as X4CrNiMo16-5-1 or 13Cr5Ni but have not been proposed for the commercial alloy PH15-5 until now ...
Dominik Brandl, Marina Lukas, Martin Stockinger, Sarah Ploberger, Gerald Ressel   +4 more
doaj   +1 more source

BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. [PDF]

, 2016
The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of ...
Barkhouse, Darryll, Li, Guichao, Lu, Bo, Wan, Juefeng, Xiao, Sheng, Yang, Lifeng, Zhang, Zhen, Zhu, Ji   +7 more
core   +2 more sources