Results 11 to 20 of about 66,016 (261)
MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis. [PDF]
PLoS ONE, 2013 MCL-1 (myeloid cell leukemia-1), a member of the BCL-2 family, has three splicing variants, antiapoptotic MCL-1L, proapoptotic MCL-1S, and MCL-1ES. We previously reported cloning MCL-1ES and characterizing it as an apoptotic molecule.
Jae-Hong Kim, Jeehyeon Bae
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مجلة علوم ذي قار, 2019 The goal of graph clustering is to partition vertices in a large graph into different clusters based on various criteria such as vertex connectivity or neighborhood similarity.
Mouiad Abid Hani
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Scientific Reports, 2017 Plants, lower eukaryotes, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that is absent in mammals. This makes the His biosynthetic route a promising target for herbicides, antifungal agents, and antibiotics ...
Milosz Ruszkowski, Zbigniew Dauter
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Evidence of austenite memory in PH 15-5 and assessment of its formation mechanism
Materials & Design, 2019 Austenite memory and subsequent spontaneous recrystallization during austenitization is stated for some types of soft martensitic stainless steels such as X4CrNiMo16-5-1 or 13Cr5Ni but have not been proposed for the commercial alloy PH15-5 until now ...
Dominik Brandl +4 more
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MCL-1 Inhibits BAX in the Absence of MCL-1/BAX Interaction [PDF]
Journal of Biological Chemistry, 2008 The BCL-2 family of proteins plays a major role in the control of apoptosis as the primary regulator of mitochondrial permeability. The pro-apoptotic BCL-2 homologues BAX and BAK are activated following the induction of apoptosis and induce cytochrome c release from mitochondria.
Marc, Germain +2 more
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Acalabrutinib Approved for MCL [PDF]
Cancer Discovery, 2018 Abstract The FDA granted accelerated approval to the second-generation BTK inhibitor acalabrutinib, which, because of its increased selectivity, seems to cause fewer side effects than ibrutinib, previously the only BTK inhibitor on the market.
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Frontiers in Plant Science, 2018 Serine hydroxymethyltransferase (SHMT, EC 2.1.2.1) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme which catalyzes the reversible serine-to-glycine conversion in either a tetrahydrofolate-dependent or -independent manner.
Milosz Ruszkowski +3 more
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MCL‐1ES, a novel variant of MCL‐1, associates with MCL‐1L and induces mitochondrial cell death
FEBS Letters, 2009 MINT‐7255756:MCL1‐ES (uniprotkb:Q07820‐2) physically interacts (MI:0914) with COX IV (uniprotkb:P13073) by anti tag coimmunoprecipitation (MI:0007)
Kim, Jae-Hong +5 more
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Seeking a MCL-1 inhibitor [PDF]
Cell Death & Differentiation, 2013 The development of small molecule drugs that mimic the actions of BH3-only proteins is one of the major triumphs of many years of apoptosis research. They are built upon a platform of an understanding the mechanisms of action of BCL-2 family proteins, and particularly a structural appreciation of the interactions between BCL-2 family proteins.
G, Brumatti, P G, Ekert
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Communications EngineeringMore than Moore technology is driving semiconductor devices towards higher complexity and further miniaturization. Device miniaturization strongly impacts failure analysis (FA), since it triggers the need for non-destructive approaches with high ...
Priya Paulachan +4 more
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