Results 71 to 80 of about 188,053 (286)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Breast Cancer Research, 2016
Background Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have ...
Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, Klaus Podar   +13 more
doaj   +1 more source

Anatomical Study With Clinical Significance of the Buccomandibular Space: A Complementary Ultrasonographic Study to Cadaveric Dissection

Clinical Anatomy, EarlyView.
ABSTRACT The buccomandibular space is a potential space located within the oral and maxillofacial regions. This morphological study aimed to provide a detailed anatomical description and ultrasonographic examination of the buccomandibular space and its adjacent structures, to discuss its clinical significance—particularly in relation to pathological ...
Hyun‐Ju Ji, Kyu‐Lim Lee, Joe Iwanaga, Koichi Watanabe, Hyoung‐Moon Kim, Hee‐Jin Kim   +5 more
wiley   +1 more source

Research Progress on Halide Solid‐State Electrolytes: Synthesis, Mechanism, and Modification

Carbon Energy, EarlyView.
This review comprehensively summarizes the research progress on halide solid‐state electrolytes, including their classifications, synthesis methods, ion conduction mechanisms, and modification strategies. It also proposes effective modification strategies to address critical issues, such as air stability and interface compatibility.
Weifeng Shen, Ping Liu, Long Wang, Haijun Yang, Jiawen Chen, Fengxiang Chen, Shenghui Shen, Guoxiang Pan, Zhong Qiu, Xinqi Liang, Yongqi Zhang, Jiayuan Xiang, Ming Song, Wei Wen, Ruyi Fang, Hui Huang, Jun Zhang, Qi Liu, Yang Xia, Wenkui Zhang, Xinhui Xia   +20 more
wiley   +1 more source

Radiographic Predictors of Medial Collateral Ligament Injury and Stability of the Elbow

JBJS Open Access, 2019
Background:. It has been postulated that injury to the medial collateral ligament (MCL) of the elbow is rare in cases of elbow fracture-dislocation, and if the MCL is torn, it does not require surgical repair.
Jordan A. Lebovic, BA, George S. Dyer, MD, Bharti Khurana, MD   +2 more
doaj   +1 more source

Mantle cell lymphoma with gastrointestinal involvement and the role of endoscopic examinations.

PLoS ONE, 2020
BackgroundStudies on gastrointestinal (GI) tract involvement in mantle cell lymphoma (MCL) are lacking. We investigated the clinical characteristics and prognosis of MCL with GI tract involvement.MethodsWe retrospectively analyzed 64 patients diagnosed ...
Han Hee Lee, Seok-Goo Cho, In Seok Lee, Hye Jin Cho, Young-Woo Jeon, Joo Hyun O, Seung Eun Jung, Byung Ock Choi, Kyung-Sin Park, Suk-Woo Yang   +9 more
doaj   +1 more source

WSPLK: A systematic approach to the thermodynamic characterization of light and heavy Mexican crude oil

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract A streamlined characterization framework (WSPLK) is presented for modelling complex reservoir fluids using cubic equations of state. The key methodological contribution is the introduction of a single global parameter ε directly into Pedersen's boiling‐point correlation, restoring pure‐component calibration and eliminating the need for ...
Angélica Merlo‐Robredo, Heber Barragán‐Mayet, Lourdes Mayet‐Cruz, José Fernando Barragán‐Aroche   +3 more
wiley   +1 more source

Bronchial bacterial colonization and the susceptibility of isolated bacteria in patients with lung malignancy

Radiology and Oncology
Postoperative pneumonia (POP) remains a leading cause of mortality following lung surgery. Recent studies have confirmed that the respiratory tract below the vocal cords is not sterile and often harbours potentially pathogenic microorganisms (PPMs ...
Petrovic Sabrina, Beovic Bojana, Tomic Viktorija, Bitenc Marko, Malovrh Mateja Marc, Dimitric Vladimir, Luznik Dane, Miklavcic Martina, Bozic Tamara, Gabrovec Tina, Sadikov Aleksander, Rozman Ales   +11 more
doaj   +1 more source

Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells [PDF]

, 2014
The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease.
Bodie, Wesley W., Dai, Yun, Felthousen, Jessica, Grant, Steven, Kramer, Lora B., Orlowski, Robert Z., Pei, Xin-Yan, Sanderson, Michael W., Shen, Shuang, Takabatake, Yukie, Youssefian, Leena E., Zhou, Liang   +11 more
core   +4 more sources

MCL — Optimization oriented programming language

Computer Physics Communications, 1989
Abstract MCL is an optimization control language associated with the recently published MERLIN optimization package. It is developed so as to aid in constructing effective minimization strategies. It is very simple and easy to master. Supports Fortran-like operations, conditional and unconditional branching, multidimensional arrays, loops, statement ...
Chassapis, C. S., Papageorgiou, D. G., Lagaris, I. E.   +2 more
openaire   +2 more sources