Results 61 to 70 of about 62,976 (303)

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Hematological indices and undiagnosed anemia among adult male patients in Makkah, Saudi Arabia

Romanian Journal of Laboratory Medicine
Background: Hematological indices are essential tools for evaluating physiological and pathological conditions, particularly anemia, which may remain undiagnosed in adult males due to the absence of specific clinical symptoms.
Zaini Rana Ghazi
doaj   +1 more source

A clinicopathological investigation on morphological alterations of red blood cells among treated and untreated type II diabetes mellitus patients

Indian Journal of Pathology and Microbiology
Introduction: The cross-sectional study was designed to analyze the morphological changes occurring in red blood cells (RBCs) among patients with type II diabetes mellitus (type II DM) and to investigate the association of these changes with various ...
Madhurima Basak, Surya Kanta Dey, Sourav Ghosh, Dipanjan Bhattacharjee, Arun Nayek, Abhishek Janaa   +5 more
doaj   +1 more source

MCV coverage assessment of different age groups^*.

, 2016
MCV coverage assessment of different age groups*.
Huiming Luo (376872), Xiang Zheng (209075), Binglin Zhang (775035), Jianfeng Liu (122580), Haijun Wang (160510), Hui Li (32376), Li Li (14993), Kongyan Meng (775034), Huaqing Wang (451126), Xiaoshu Zhang (775032), Qiru Su (455730), Lixin Hao (775033), Ningjing Zhang (775031), Chao Ma (207385)   +13 more
core   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Etiological Profile of Macrocytic Anemia in Patients Presenting to a Tertiary Care Hospital

Assam Journal of Internal Medicine
Background: Macrocytic anemia is a common hematological finding with a wide range of causes, from nutritional deficiencies to systemic illnesses and bone marrow disorders.
Akhila Nampally, Deme Swaroopa, Adiraju Krishna Prasad   +2 more
doaj   +1 more source

Cost-effectiveness of alternate strategies for childhood immunization against meningococcal disease with monovalent and quadrivalent conjugate vaccines in Canada.

PLoS ONE, 2017
BackgroundPublic health programs to prevent invasive meningococcal disease (IMD) with monovalent serogroup C meningococcal conjugate vaccine (MCV-C) and quadrivalent meningococcal conjugate vaccines (MCV-4) in infancy and adolescence vary across Canadian
Thomas E Delea, Derek Weycker, Mark Atwood, Dion Neame, Fabián P Alvarez, Evelyn Forget, Joanne M Langley, Ayman Chit   +7 more
doaj   +1 more source

Quantitation of human seroresponsiveness to Merkel cell polyomavirus.

PLoS Pathogens, 2009
Merkel cell carcinoma (MCC) is a relatively uncommon but highly lethal form of skin cancer. A majority of MCC tumors carry DNA sequences derived from a newly identified virus called Merkel cell polyomavirus (MCV or MCPyV), a candidate etiologic agent ...
Diana V Pastrana, Yanis L Tolstov, Jürgen C Becker, Patrick S Moore, Yuan Chang, Christopher B Buck   +5 more
doaj   +1 more source

DETECTing Merkel Cell Polyomavirus in Merkel Tumors

Frontiers in Molecular Biosciences, 2020
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCV) T antigen expression, post-integration (~80% cases), or by UV-mediated DNA damage.
Reety Arora, Komal Gupta, Komal Gupta, Anjali Vijaykumar, Sudhir Krishna   +4 more
doaj   +1 more source

Trichodysplasia spinulosa-associated polyomavirus (TSV) and Merkel cell polyomavirus: correlation between humoral and cellular immunity stronger with TSV. [PDF]

PLoS ONE, 2012
Merkel Cell Polyomavirus (MCV) is a common infectious agent likely to be involved in the pathogenesis of most Merkel cell carcinomas (MCC). Trichodysplasia spinulosa-associated polyomavirus (TSV), which exhibit high seroprevalence in general population ...
Arun Kumar, Anu Kantele, Tommi Järvinen, Tingting Chen, Heli Kavola, Mohammadreza Sadeghi, Klaus Hedman, Rauli Franssila   +7 more
doaj   +1 more source