Results 131 to 140 of about 384,184 (313)

Enterprise Modeling for Information System Development within MDA

Objektorientēta analīze piedāvā pusformālas lietošanas gadījumu vadāmas metodes problēmas domēna modelēšanai no skaitļošanas neatkarīga skatu punkta. Piedāvātā pieeja – Topoloģiskā Funkcionēšanas Modelēšana Modeļvadāmai Arhitektūrai (TFM4MDA) palielina ...
Nazaruka, Ērika, Osis, Jānis
core  

Zakes Mda

, 2015
Book chapter on Zakes Mda, one of Southern Africa’s most respected, innovative and audacious playwright, artist, poet and novelist. The chapter discusses some Mda's seminal plays including "And the Girls in their Sunday Dresses"; "The Final Dance"; "The ...
Igweonu, K.
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Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

A Model Driven Approach to Model Transformations

, 2003
The OMG's Model Driven Architecture (MDA) initiative has been the focus of much attention in both academia and industry, due to its promise of more rapid and consistent software development through the increased use of models.
Laurence Tratt, Tony Clark, Venkatesh, R., R. Venkatesh, Appukuttan, Biju K., Biju Appukuttan, Tratt, Laurence, Clark, Tony, Reddy, Sreedhar, Sreedhar Reddy   +9 more
core  

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

APPLICATION OF SOLID-STATE TRACK DETECTORS FOR MEASUREMENT OF THE LOW-LEVEL ACTIVITY OF ALPHA-EMITTERS

Радиационная гигиена, 2016
Alpha spectrometry approach using solid state nuclear track detectors  of CR-39 type is considered within the energy range 4-6 MeV. Experimental information obtaining stages are described from solid state nuclear track detectors  irradiation procedure to
S. G. Gorbachev
doaj  

PSYNDEX Tests Review für MDA 10+ - MATHEMATISCHE DENKAUFGABEN 10+

, 1982
This is a PSYNDEX Tests Review of MDA 10+ - MATHEMATISCHE DENKAUFGABEN 10+. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Bartel, Hans
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source