Results 41 to 50 of about 5,869 (296)
BMC Bioinformatics, 2021 Background With the rapid development of various advanced biotechnologies, researchers in related fields have realized that microRNAs (miRNAs) play critical roles in many serious human diseases.
Feng Zhou +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Human Behavior and Emerging TechnologiesCurrent research suggests that some emerging adults may not view mobile dating applications (MDAs) as helpful for forming relationships, rather seeing the applications as a means for sexual encounters or entertainment.
Michael R. Langlais, Celia T. Lee
doaj +1 more source
Results of literature search for 18 highly plausible MDAs.
, 2015 Result of literature search for 18 highly plausible MDAs. MDA: miRNA-disease association; DG: disease-related gene; PIS: protein interaction score; N/A: not available.Results of literature search for 18 highly plausible MDAs.
Xiaodan Chu (785721) +10 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Materials Research Express, 2021 Chromium (VI) electroplating plays a vital role in the surface engineering industry for metallic materials due to its high hardness and excellent chemical stability.
Xia Lou +6 more
doaj +1 more source
Measurement invariance of the Multidimensional Depression Assessment Scale (MDAS) across gender and ethnic groups of Asian, Caucasian, Black, and Hispanic [PDF]
, 2022 BackgroundMajor Depressive Disorder is a severe and highly disabling mental illness. Almost all self-reported questionnaires have overlooked the interpersonal symptoms of depression which are important across gender and culture.
Chan, Y.S. +7 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A novel mutation of HOXA11 in a patient with septate uterus
Orphanet Journal of Rare Diseases, 2017 Background The etiology of Müllerian duct anomalies (MDAs) is poorly understood at present. The HOXA11 gene is crucial for the development of the Müllerian duct.
Ying Zhu +7 more
doaj +1 more source