Results 91 to 100 of about 22,143,644 (312)

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

BMC Cancer, 2014
BackgroundThe anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evaluated its chemotherapeutic and ...
Liqun Huang, C. Wong, G. Mackenzie, Yu Sun, Ka-Wing Cheng, Kvetoslava Vranková, N. Alston, N. Ouyang, B. Rigas   +8 more
semanticscholar   +1 more source

Maximal Rashba Splitting in GeTe/Bi2Te3 Heterostructures via Strong Band Bending

Advanced Science, EarlyView.
An unprecedented strength of Rashba effect with ER = 0.57 eV, k0=0.16Å−1$\;{k_0} = 0.16\;{\mathrm{\AA}^{ - 1}}$ and αR=6.86eV·Å$ {\alpha _{\mathrm{R}}} = 6.86{\mathrm{\;eV}} \cdot {\mathrm{\AA}}$ in GeTe (1 nm)/Bi2Te3 (1 QL) heterostructure. The enhanced Rashba is origined from the band bending effect in the heterojunction region of GeTe /Bi2Te3 ...
Qing‐Lin Yang, Xu Yang, Jia‐Wan Li, Yan Li, Jin Tang, Hai‐Feng Du, Zi‐Zhao Gong, Hao‐Pu Xue, Jia‐Nan Liu, Zhuo Deng, Peng‐Tao Yang, Xiang‐Qun Zhang, Wei He, Yusheng Hou, Zhao‐Hua Cheng   +14 more
wiley   +1 more source

Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC

PLoS ONE, 2014
Conjugated vaccines consisting of flagellin and antigen activate TLR5 and induce strong innate and adaptive immune responses. Objective of the present study was to gain further insight into the mechanisms by which flagellin fusion proteins mediate their ...
S. Schülke, S. Wolfheimer, G. Gadermaier, A. Wangorsch, S. Siebeneicher, P. Briza, I. Spreitzer, D. Schiller, Bettina Loeschner, S. Uematsu, B. Ryffel, S. Akira, Z. Waibler, S. Vieths, M. Toda, S. Scheurer   +15 more
semanticscholar   +1 more source

Reciclaje de pavimentos : estudio de las ventajas económicas del reciclaje en frío in situ de pavimentos asfalticos [PDF]

, 2015
En los procesos de mantenimiento y rehabilitación de pavimentos, se deben definir los objetivos, bien sea para realizar unas reparaciones superficiales sobre daños generados por el agua como consecuencia de fallas en los drenajes, o bien realizar una ...
Restrepo Sierra, Héctor Albeiro, Stephens Zapata, Steve Alexander   +1 more
core  

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Secondary-electron-emission losses in multistage depressed collectors and traveling-wave-tube efficiency improvements with carbon collector electrode surfaces [PDF]

Secondary-electron-emission losses in multistage depressed collectors (MDC's) and their effects on overall traveling-wave-tube (TWT) efficiency were investigated. Two representative TWT's and several computer-modeled MDC's were used.
Ebihara, B. T., Ramins, P.
core   +1 more source

Rehabilitación de pavimentos con mezclas asfálticas convencionales y modificadas con polímeros en la malla vial del municipio de Itagüí [PDF]

, 2014
El Municipio de Itagüí en los últimos años ha sufrido un crecimiento elevado en la circulación de vehículos, especialmente los comerciales debido a que es una ciudad industrial y comercial en donde se ubican importantes fábricas a nivel regional y ...
Hernández Hernández, Juan David, Rosero Vega, Darwin Duver   +1 more
core  

d‐Wave Fermi Surface Instability in the Nematic Phase of Two Monolayer FeSe/SrTiO3

Advanced Science, EarlyView.
Angle‐resolved photoemission spectroscopy reveals a d‐wave nematic order in two‐monolayer FeSe/SrTiO3, showing degenerate dxz/dyz bands at Γ but a pronounced splitting at M. This momentum‐dependent anisotropy identifies the nematicity as a d‐wave Fermi surface (Pomeranchuk) instability, highlighting 2D FeSe as a model platform to explore the interplay ...
C. Y. Tang, X.‐L. Peng, Y.‐H. Yuan, P. Zhang, G.‐N. Phan, S.‐Y. Gao, Y.‐B. Huang, L.‐Y. Kong, T. Qian, W. Li, Q.‐K. Xue, Z.‐Q. Wang, K. Jiang, Y.‐J. Sun, H. Ding   +14 more
wiley   +1 more source

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.

Neoplasia, 2013
Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited treatment options for pancreatic cancer underscore the need for more efficient agents.
G. Mackenzie, Lauren E Bartels, Gang Xie, I. Papayannis, N. Alston, Kvetoslava Vranková, N. Ouyang, B. Rigas   +7 more
semanticscholar   +1 more source

Interpreting Helioseismic Structure Inversion Results of Solar Active Regions

, 2008
Helioseismic techniques such as ring-diagram analysis have often been used to determine the subsurface structural differences between solar active and quiet regions.
A.G. Kosovichev, A.G. Kosovichev, A.G. Kosovichev, A.G. Kosovichev, C.-H. Lin, C.A. Iglesias, C.L. Raftery, Chia-Hsien Lin, D.A. Haber, D.R. Alexander, E. Priest, E.J. Rhodes Jr., F. Hill, F.J. Rogers, F.P. Pijpers, F.P. Pijpers, H.M. Antia, J. Lin, J. Patron, J. Schou, J.M. Bahcall, L.H. Li, L.H. Li, Linghuai Li, P. Demarque, S. Basu, S. Basu, Sarbani Basu, T.J. Lydon, T.L. Duvall Jr., V.V. Zharkova, W.A. Dziembowski   +31 more
core   +1 more source