Results 101 to 110 of about 12,124,912 (231)

Cellular Aggregation Facilitates Anoikis in MDCK Cells

The Journal of Physiological Sciences, 2008
Anoikis is a specific type of apoptosis caused by the detachment of anchorage-dependent cells from their supportive matrix. Aggregation of suspended cells is believed to suppress anoikis. Here we describe the effects of cellular aggregation on anoikis in Madin-Darby canine kidney (MDCK) cells.
openaire   +3 more sources

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells

PLoS ONE, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM). Integrin heterodimers orchestrate dynamic assembly and disassembly of cell-ECM connections and thereby convey biochemical and mechanical information from the ECM into cells. However,
Teräväinen, Terhi P., Myllymäki, Satu M., Friedrichs, Jens, Strohmeyer, Nico; id_orcid0000-0002-5985-9800, Moyano, Jose V., Wu, Chuanyue, Matlin, Karl S., Muller, Daniel J., Manninen, Aki   +8 more
openaire   +8 more sources

O‐Glycosylation of E‐Cadherin Induced by Endoplasmic Reticulum Stress Negatively Regulates Cell Polarity and Proliferation in Acute Kidney Injury

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ER stress could cause the O‐glycosylation of E‐cadherin in RTECs, leading to dysregulation of cell polarity and proliferation. ER stress inhibitors alleviate kidney injury and promote the recovery of kidney function. These findings provide new molecular targets and intervention strategies for the clinical treatment of AKI. ABSTRACT The loss of polarity
Yingjia Zhang, Weidong Zhang, Qingwu Liao, Zhaoxing Sun, Weize Chen, Xiaoqiang Ding, Shuan Zhao   +6 more
wiley   +1 more source

SNHG15 Positively Regulates Influenza Virus Infection Through Its Association With miR‐153 and RABL2A

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Influenza viruses cause seasonal epidemics, and current vaccines do not fully protect against them. This study focuses on long non‐coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in various biological processes. We identified 17 lncRNAs altered by the influenza virus.
Samuel Pushparaj, Kishore Vaddadi, Chaoqun Huang, Yurong Liang, Dao Xu, Gayan Bamunuarachchi, Prince Jhandai, Keerthana Santhosh, Elizabeth Varghese, Lin Liu   +9 more
wiley   +1 more source

Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus

Vaccine, 2019
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of influenza vaccine seed viruses for humans on the basis of primary virus isolation efficiency, growth ability, genetic stability of the hemagglutinin (HA)
Kazuya, Nakamura, Yuichi, Harada, Hitoshi, Takahashi, Heidi, Trusheim, Roth, Bernhard, Itsuki, Hamamoto, Asumi, Hirata-Saito, Teruko, Ogane, Katsumi, Mizuta, Nami, Konomi, Yasushi, Konomi, Hideki, Asanuma, Takato, Odagiri, Masato, Tashiro, Norio, Yamamoto   +14 more
openaire   +2 more sources

Covalently Immobilized Lignin–Xanthene Conjugates for Persistent Surface Photochemistry and Self‐Sterilizing Interfaces Under Ambient Visible Light

Macromolecular Rapid Communications, Volume 47, Issue 15, 4 August 2026.
Bio‐derived lignin–Eosin Y macromolecular networks are developed as visible‐light‐responsive self‐sterilizing coatings that generate reactive oxygen species without leaching. The spray‐coated photopolymerized surfaces exhibit durable antibacterial and antiviral activity under ambient light for extended periods, demonstrating a scalable and sustainable ...
Euna Oh, Surjith Kumaran, Sumin Han, Kiseok Lee, Hyerin Shin, Seokmin Oh, Dae‐Hong Ko, Hyo‐Jick Choi   +7 more
wiley   +1 more source

Replication kinetics of novel swine influenza A viruses: an approach to vaccine production

Austral Journal of Veterinary Sciences
Novel swine Influenza A viruses (IAVs) have been described in South America. The objective of this study was to evaluate the replication kinetics of novel swine IAVs as a first step for vaccine production.
Rodrigo Tapia, Victor Neira, Rafael Medina   +2 more
doaj   +1 more source

The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson, Dillon Popat, Kathy Sengmany, Miguel C. Silva, Steven J. Charlton, Charles S. Lay   +5 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, Volume 7, Issue 4, August 2026.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source