Results 1 to 10 of about 32,238 (217)

SLC35A2 Deficiency Promotes an Epithelial-to-Mesenchymal Transition-like Phenotype in Madin–Darby Canine Kidney Cells [PDF]

Cells, 2022
In mammalian cells, SLC35A2 delivers UDP–galactose for galactosylation reactions that take place predominantly in the Golgi lumen. Mutations in the corresponding gene cause a subtype of a congenital disorder of glycosylation (SLC35A2-CDG).
Magdalena Kot, Ewa Mazurkiewicz, Maciej Wiktor, Wojciech Wiertelak, Antonina Joanna Mazur, Andrei Rahalevich, Mariusz Olczak, Dorota Maszczak-Seneczko   +7 more
doaj   +2 more sources

Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity [PDF]

Journal of Lipid Research, 2015
Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization.
Nicolás Octavio Favale, Bruno Jaime Santacreu, Lucila Gisele Pescio, Maria Gabriela Marquez, Norma Beatriz Sterin-Speziale   +4 more
doaj   +3 more sources

Canid herpesvirus 1 Preferentially Infects Polarized Madin-Darby Canine Kidney Cells from the Basolateral Surface [PDF]

Viruses, 2022
Canid herpesvirus 1 (CHV-1) infects polarized canine epithelia. Herein, we present our initial work characterizing CHV-1 infection of Madin-Darby canine kidney (MDCK) cells that were polarized on trans-wells.
Mohamed Eisa, Samar Micky, Angela Pearson   +2 more
doaj   +2 more sources

Epithelial sheet folding induces lumen formation by Madin-Darby canine kidney cells in a collagen gel. [PDF]

PLoS ONE, 2014
Lumen formation is important for morphogenesis; however, an unanswered question is whether it involves the collective migration of epithelial cells. Here, using a collagen gel overlay culture method, we show that Madin-Darby canine kidney cells migrated ...
Sumire Ishida, Ryosuke Tanaka, Naoya Yamaguchi, Genki Ogata, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga   +6 more
doaj   +2 more sources

Endocytosis in filter-grown Madin-Darby canine kidney cells [PDF]

The Journal of cell biology, 1989
The nitrogen-containing bisphosphonates used for management of the patients with osteoporosis were reported to influence the function of renal tubular cells.
Bomsel, M., Gruenberg, J., Parton, R. G., Prydz, K., Simons, K.   +4 more
core   +5 more sources

Environmental hyperosmolality regulates phospholipid biosynthesis in the renal epithelial cell line MDCK [PDF]

Journal of Lipid Research, 2013
Hyperosmolality is a key signal for renal physiology. On the one hand, it contributes to the differentiation of renal medullary structures and to the development of the urinary concentrating mechanism. On the other, it is a stress factor.
Cecilia I. Casali, Karen Weber, Nicolás O. Favale, María C. Fernández Tome   +3 more
doaj   +4 more sources

Inhibitory actions by ibandronate sodium, a nitrogen-containing bisphosphonate, on calcium-activated potassium channels in Madin–Darby canine kidney cells [PDF]

Toxicology Reports, 2015
The nitrogen-containing bisphosphonates used for management of the patients with osteoporosis were reported to influence the function of renal tubular cells.
Sheng-Nan Wu, Hui-Zhen Chen, Yu-Hung Chou, Yan-Ming Huang, Yi-Ching Lo   +4 more
doaj   +2 more sources

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells [PDF]

, 2013
Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics during ...
A Benmerah, A Gassama-Diagne, A Le Bivic, A Oztan, AL Rozelle, AV Oleinikov, BA Potter, BM Collins, Brianne E. Docter, Christina M. Szalinski, Christopher J. Guerriero, CJ Guerriero, CJ Maples, CJ Merrifield, CJ Merrifield, CN Antonescu, D Padron, DJ James, DK Strickland, F Gong, F Martin-Belmonte, F Martin-Belmonte, G Apodaca, G Apodaca, G Di Paolo, G Di Paolo, G Rohde, G Spudich, G Spudich, Gerard Apodaca, H Ishihara, H Ishihara, HY Naim, HY Naim, I van den Bout, J Hyman, J Zheng, JC Loijens, JM Anderson, Joshua Z. Rappoport, JR Henkel, JZ Rappoport, KM Vasudevan, KM Weixel, L Fang, LA Volpicelli-Daley, LA Volpicelli-Daley, LM Traub, M Bens, M Jost, M Krauss, M Nagai, MA Barbieri, MA Lemmon, MA Lokuta, MA Puthenveedu, Manojkumar A. Puthenveedu, MG Ford, Núria M. Pastor-Soler, O Cremona, O Idevall-Hagren, Ora A. Weisz, P Khandelwal, P Varnai, PC Stolt, PP Breitfeld, R Rohatgi, R Rohatgi, R Rojas, R Rojas, R Zoncu, RV Stahelin, RW Holz, S Benesch, S Boulant, S Cui, S Hardy, S Mukherjee, SF Bairstow, SJ Mundell, SK Mishra, T Hyman, T Itoh, TA Gottlieb, V Haucke, Wily G. Ruiz, Y Aikawa, Y Wang, Youssef Rbaibi, YS Mao   +89 more
core   +17 more sources

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

Molecular Pharmaceutics, 2023
Madin-Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low endogenous drug transporter protein levels make them an amenable system to investigate transepithelial permeation and drug transporter protein activity after their transfection.
Matthew D. Harwood, Katharina Zettl, Manuel Weinheimer, Venkatesh Pilla-Reddy, Hong Shen, Frank Jacobs, Xiaoyan Chu, Felix Huth, Masanori Nakakariya, Paresh P. Chothe, Sibylle Neuhoff, Jacek R. Wiśniewski   +11 more
openaire   +3 more sources

Induction of Epithelial-mesenchymal Transition in MDCK II Cells

Bio-Protocol, 2021
Epithelial-mesenchymal transition (EMT) is a reversible process of epithelial cell transdifferentiation into a mesenchymal cell, that enables initiation of cell migration.
Agnieszka Pastula, Richard Lundmark
doaj   +1 more source