Results 41 to 50 of about 19,777 (180)

Two DNA aptamers against avian influenza H9N2 virus prevent viral infection in cells. [PDF]

PLoS ONE, 2015
New antiviral therapy for pandemic influenza mediated by the H9N2 avian influenza virus (AIV) is increasingly in demand not only for the poultry industry but also for public health.
Yuewei Zhang, Ziqiang Yu, Fei Jiang, Ping Fu, Junjun Shen, Wenxue Wu, Jinxiang Li   +6 more
doaj   +1 more source

NaCl transport by Madin Darby canine kidney cyst epithelial cells

Kidney International, 1992
The mechanism of NaCl transport across the epithelium of intact MDCK cysts grown in a collagen gel matrix was investigated. Double-barreled microelectrodes were used to measure basolateral membrane PD (Vbl), transepithelial PD (Vt), and intracellular (Cli) and intralumenal (Clcy) Cl- activities in cysts under different conditions. In a control Ringer's
Macias, William L., McAteer, James A., Tanner, George A., Fritz, Alison L., Armstrong, William McD   +4 more
openaire   +2 more sources

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Cell membrane disruption stimulates cAMP and Ca2+ signaling to potentiate cell membrane resealing in neighboring cells

Biology Open, 2017
Disruption of cellular plasma membranes is a common event in many animal tissues, and the membranes are usually rapidly resealed. Moreover, repeated membrane disruptions within a single cell reseal faster than the initial wound in a protein kinase A (PKA)
Tatsuru Togo
doaj   +1 more source

Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density

Nature Communications, 2023
Changes in tissue geometry during developmental processes are associated with collective migration of cells. Recent experimental and numerical results suggest that these changes could leverage on the coexistence of nematic and hexatic orientational order
Julia Eckert, Benoît Ladoux, René-Marc Mège, Luca Giomi, Thomas Schmidt   +4 more
doaj   +1 more source

Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells

Cytoskeleton, EarlyView.
ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz, Lakshmi Nyapathi‐Gopinath, Jonah Luka Voigt, Katharina Weber, Marlene Maager, Veselin Nasufovic, Elisabetta Ada Cavalcanti‐Adam   +6 more
wiley   +1 more source

Multigram Scale Synthesis and Anti-Influenza Activity of 3-Indoleacetonitrile Glucosides

Natural Product Communications, 2020
Indole-3-acetonitrile-6- O-β - d -glucopyranoside 1 is a simple alkaloid with anti-influenza A virus activity extracted from Radix isatidis . Herein, a concise and practical total synthetic route of 1 was presented, starting from 6-benzyloxyindole on a ...
Jianghong Dong, Fengmei Yan, Shuang Li, Zewen Li, Yuanhang Qin   +4 more
doaj   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Intranasal vaccination with an engineered influenza virus expressing the receptor binding subdomain of botulinum neurotoxin provides protective immunity against botulism and influenza

Frontiers in Immunology, 2015
Influenza virus is a negative, segmented RNA virus without DNA intermediate. This makes it safer as a vaccine delivery vector than most DNA viruses that have potential to integrate their genetic elements into host genomes.
Junwei eLi, Diana eDiaz-Arévalo, Yanping eChen, Mingtao eZeng   +3 more
doaj   +1 more source

O‐Glycosylation of E‐Cadherin Induced by Endoplasmic Reticulum Stress Negatively Regulates Cell Polarity and Proliferation in Acute Kidney Injury

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ER stress could cause the O‐glycosylation of E‐cadherin in RTECs, leading to dysregulation of cell polarity and proliferation. ER stress inhibitors alleviate kidney injury and promote the recovery of kidney function. These findings provide new molecular targets and intervention strategies for the clinical treatment of AKI. ABSTRACT The loss of polarity
Yingjia Zhang, Weidong Zhang, Qingwu Liao, Zhaoxing Sun, Weize Chen, Xiaoqiang Ding, Shuan Zhao   +6 more
wiley   +1 more source