Results 31 to 40 of about 32,238 (217)

TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells [PDF]

, 2014
Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+)
Apodaca, Gerard, Clayton, Dennis R., Fukuda, Mitsunori, Gallo, Luciana I., Jiang, Yu, Li, Min, Liao, Yong, Liu, Yong-Jian, Ruiz, Wily G., Yin, Xiao-Ming   +9 more
core   +2 more sources

NaCl transport by Madin Darby canine kidney cyst epithelial cells

Kidney International, 1992
The mechanism of NaCl transport across the epithelium of intact MDCK cysts grown in a collagen gel matrix was investigated. Double-barreled microelectrodes were used to measure basolateral membrane PD (Vbl), transepithelial PD (Vt), and intracellular (Cli) and intralumenal (Clcy) Cl- activities in cysts under different conditions. In a control Ringer's
Macias, William L., McAteer, James A., Tanner, George A., Fritz, Alison L., Armstrong, William McD   +4 more
openaire   +2 more sources

Regulation of epithelial migration by epithelial cell adhesion molecule requires its Claudin-7 interaction domain. [PDF]

PLoS ONE, 2018
Epithelial cell adhesion molecule (EpCAM) is a glycoprotein on the surface of epithelial cells that is essential for intestinal epithelial integrity and expressed at high levels in many epithelial derived cancers and circulating tumor cells. Here we show
Angela I M Barth, Honesty Kim, Ingmar H Riedel-Kruse   +2 more
doaj   +1 more source

Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex [PDF]

, 2002
The functions of the two proteins defective in autosomal dominant polycystic kidney disease, polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that they may heterodimerize to form a "polycystin complex" involved ...
Ackermann, Bergsma, Boletta, Cai, Charron, Chen, Foggensteiner, Gallagher, Gonzalez-Perrett, Green, Grupp, Hanaoka, Huan, Hughes, Ibraghimov Beskrovnaya, Ibraghimov Beskrovnaya, Jat, Jat, Lehtonen, Lohning, Lu, Man, Markowitz, Mochizuki, Moy, Nathke, Obermuller, Olmsted, Ong, Ong, Ong, Ong, Pollack, Pritchard, Putney, Qian, Rothman, Scheffers, Tsiokas, Vassilev, Ward, Watnick, Wu, Xu   +43 more
core   +1 more source

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection [PDF]

, 2023
Recent human H3N2 influenza A viruses have evolved to employ elongated glycans terminating in α2,6-linked sialic acid as their receptors. These glycans are displayed in low abundancies by (humanized) Madin-Darby Canine Kidney cells, which are commonly ...
Bestebroer, Theo, Boons, Geert Jan, Damen, Mirjam J.A., de Vries, Robert P., Fouchier, Ron A.M., Herfst, Sander, Lexmond, Pascal, Maliepaard, Joshua C.L., Qiu, Boning, Reiding, Karli R., Snijder, Joost, Spruit, Cindy M., Sweet, Igor R.   +12 more
core   +2 more sources

cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

Viruses, 2017
MicroRNAs regulate multiple aspects of the host response to viral infection. This study verified that the expression of cfa-miR-143 was upregulated in vivo and in vitro by canine influenza virus (CIV) H3N2 infection. To understand the role of cfa-miR-143
Pei Zhou, Liqing Tu, Xi Lin, Xiangqi Hao, Qingxu Zheng, Weijie Zeng, Xin Zhang, Yun Zheng, Lifang Wang, Shoujun Li   +9 more
doaj   +1 more source

A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis

iScience, 2020
Summary: Madin-Darby canine kidney II (MDCKII) cells are widely used to study epithelial morphogenesis. To better understand this process, we performed time course RNA-seq analysis of MDCKII 3D cystogenesis, along with polarized 2D cells for comparison ...
Tianfang Wang, Sang-Ho Kwon, Xiao Peng, Severine Urdy, Zefu Lu, Robert J. Schmitz, Stephen Dalton, Keith E. Mostov, Shaying Zhao   +8 more
doaj   +1 more source

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Frontiers in Cell and Developmental Biology, 2022
Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis.
Lisette Sandoval, Mariana Labarca, Mariana Labarca, Claudio Retamal, Claudio Retamal, Paula Sánchez, Juan Larraín, Alfonso González, Alfonso González, Alfonso González   +9 more
doaj   +1 more source

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species

Pathogens
Swine enteric coronaviruses (SECoVs), including porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), have caused high mortality in ...
Zhongyuan Li, Yunyan Chen, Liang Li, Mei Xue, Li Feng   +4 more
doaj   +1 more source