Results 111 to 120 of about 40,945 (273)

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth, Erowid, Fire, Martínez Vivot, Rocío, Pallavicini, Carla, Sanz, Camila, Tagliazucchi, Enzo Rodolfo, Zamberlan, Federico   +6 more
core   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

MDMA Impairs Response to Water Intake in Healthy Volunteers

Advances in Pharmacological Sciences, 2016
Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies.
Matthew J. Baggott, Kathleen J. Garrison, Jeremy R. Coyle, Gantt P. Galloway, Allan J. Barnes, Marilyn A. Huestis, John E. Mendelson   +6 more
doaj   +1 more source

Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy [PDF]

, 2017
3,4-Methylenedioxymethylamphetamine (MDMA;‘ecstasy’) produces prosocial subjective effects that may extend to affiliative feelings towards the self. Behavioural techniques can produce similar self-directed affiliation. For example, compassionate imagery (
Alotaibi, MR, Blagbrough, IS, Falconer, CJ, Freeman, TP, Husbands, SM, Kamboj, SK, Walldén, YSE   +6 more
core  

How to Change Minds Ethically: Doxastic Vulnerability, Epistemic Harm Reduction, and the Role of Therapists in Psychedelic Therapy

Journal of Applied Philosophy, EarlyView.
ABSTRACT Psychedelics offer an intriguing novel method for changing minds, supposedly by destabilizing the neurobiology of the belief system. The resulting power to change minds raises ethical and epistemic concerns. This article examines the epistemic status of psychedelic experiences and suggests a skeptical attitude towards beliefs formed under ...
Jan Christoph Bublitz
wiley   +1 more source

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility [PDF]

, 2015
Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy
Abad, Sonia, Auladell i Costa, M. Carme, Camarasa García, Jordi, Camins Espuny, Antoni, Escubedo Rafa, Elena, Junyent Herena, Fèlix, Pallàs i Llibería, Mercè, 1964-, Pubill Sánchez, David   +7 more
core   +2 more sources

Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA

NeuroImage, 2019
One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response.
O. Dipasquale, P. Selvaggi, M. Veronese, A. Gabay, F. Turkheimer, M. Mehta   +5 more
semanticscholar   +1 more source

Ecstasy tablets intoxication with lethal autcome [PDF]

, 2007
Background. Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4 ...
Tomašević Gordana, Đorđević Snežana   +1 more
core   +1 more source

Innovative Nanomaterial‐Based Approaches for the Recognition of Amphetamine in Attention Deficit Hyperactivity Disorder Management

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods. This review examines innovative nanomaterial‐based approaches for AMP detection, emphasizing their advantages over conventional analytical ...
Ilghar Zeinaly, Ghazal Koohkansaadi, Majid Hassanzadeh‐Khanmiri, Ahmad Mobed, Saeid Charsouei, Arash Mohagheghi   +5 more
wiley   +1 more source

Rare but relevant: MDMA and hyponatraemia

Addiction, Volume 121, Issue 3, Page 713-718, March 2026.
Abstract Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonly used psychoactive drugs, specifically among young adults and in nightlife and recreational party contexts.
Maria Rita Garcia, Nelson G. M. Gomes, Diana Dias‐da‐Silva   +2 more
wiley   +1 more source